运用复杂网络分析中医治疗乙肝病毒相关性肾炎的用药规律  

Regularity Analysis of Chinese Medication for HBV-GN Based on Effective Cases with Complex Networks

作　　者：张志奎[1] 王耀光[2] 

机构地区：[1]天津中医药大学,天津300193 [2]天津中医药大学第一附属医院,天津300193

出　　处：《中医药学报》2017年第3期31-34,共4页Acta Chinese Medicine and Pharmacology

基　　金：国家自然科学基金面上项目(81573888)

摘　　要：目的:探讨中医药治疗乙肝病毒相关性肾炎的用药规律。方法:以"乙肝病毒相关性肾炎""中医"等为主题词,检索中国知网、中文科技期刊全文数据、万方数据库近20年的文献,选取中医治疗本病效果明显的文献。运用Epi Data3.1建立中药复方数据库。应用SPSS20.0分析单味中药的使用频次、频率。用Medisco-3S对两两中药之间的关联性进行分析。结果:符合纳入标准的文献92篇,涉及中药152味,累计使用1 184次;使用频率超过1%的中药30味,累计使用811次。常用配伍药物组合为:生黄芪、柴胡、白术、丹参、茯苓、白花蛇舌草、山药和茵陈。结论:通过复杂网络分析文献中所用中医药治疗本病的用药规律,得出健脾益肾、清热解毒的治法,为临床用药提供一定的指导意义和统计学证据。Objective ： To explore the regularity of Chinese medication in treating HBV - GN. Methods ： Effective cases of HBV - GN were selected according to the inclusion criteria on the basis of reviewing literatures published from 2007 to 2016 in the databases of Chinese National Knowledge Infrastructure（ CNKI）, Chinese Science and Technology Periodical Full Text （VIP） and Wanfang Data. The search words used for the retrieval were ‘ HBV - GN＇ and ‘ traditional Chinese medicine＇. The herbs used were collected from the database established with EpiData3.1. The application frequency of each herb was counted with SPSS20.0. The correlations of each two herbs were analysed with Medisco -3S. Results： 152 herbs were used, and repeated 1184 times altogether in 92 papers. The number of the herbs, with more than 1% application frequency, was 30; and the herbs repeated 811 times altogether. The commonly herbs used for the treatment of HBV - GN were Astragalus Root （ Huang Qi）, Radix Bupleuri （ Chai Hu）, Roizoma Atractylodis Macrocephalae （ Bai Zhu）, Salvia Miltiorrhiza（ Dan Shen）, Poria Cocos（ Fu Ling）, Herba Hedyotis（ Bai Hua She She Cao）, Rhizoma Di- oscoreae （Shan Yao）, and Artemisia Capillaris Thunb（ Yin Chen Hao）. Conclusion： The method of enforcing spleen and nourishing kidney, and clearing away heat and toxin is concluded for treating HBV -GN by analyzing the medication regularity, and it may provide useful information for clinical treatment and related research in the future.

关 键 词：乙肝病毒相关性肾炎 中医治疗 复杂网络 用药规律 

分 类 号：R692.3[医药卫生—泌尿科学]