银杏叶提取物联合糖皮质激素治疗特发性肺纤维化疗效及对血清TGF-β_1、IL-13、SOD、MDA的影响  

Effect of Ginkgo biloba extract combined with glucocorticoid on idiopathic pulmonary fibrosis and its influence on serum TGF-beta1,IL-13,SOD and MAD

作　　者：潘勇军 刘红霞 

机构地区：[1]鄂东医疗集团市中医医院,湖北黄石435000

出　　处：《现代中西医结合杂志》2017年第21期2312-2315,共4页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察银杏叶提取物联合糖皮质激素治疗特发性肺纤维化(IPF)的疗效及对血清转化生长因子-β_1(TGF-β_1)、白细胞介素-13(IL-13)、血清超氧化物歧化酶(SOD)、丙二醛(MDA)水平的影响。方法将86例IPF患者随机分为观察组43例及对照组43例,对照组给予糖皮质激素治疗,观察组在常规治疗基础上给予银杏叶提取物治疗,疗程12周。观察2组治疗前后血气分析、肺功能、肺纤维指标变化情况;检测2组治疗前后血清TGF-β_1、IL-13、SOD、MDA水平。结果 2组治疗后p(O_2)、Sa(O_2)均明显升高(P均<0.05),p(CO_2)、p_(A-a)(O_2)均明显降低(P均<0.05),且观察组p(O_2)、p_(A-a)(O_2)改善情况均优于对照组(P均<0.05);2组治疗后FVC、FEV_1/FVC、MVV、DLCO均明显升高(P均<0.05),且观察组上述指标改善情况均明显优于对照组(P均<0.05);2组治疗后PCⅢ、CⅣ、PICP、LN均明显降低(P均<0.05),且观察组上述指标改善情况均明显优于对照组(P均<0.05);2组治疗后血清TGF-β_1、IL-13、MDA水平均明显降低(P均<0.05),SOD水平均明显升高(P均<0.05),且观察组上述指标改善情况均优于对照组(P均<0.05)。结论银杏叶提取物联合糖皮质激素能够显著改善IPF患者动脉血气指标及肺功能,并阻断肺纤维化进程,可能与降低血清TGF-β_1、IL-13、MDA水平,提高SOD活性有关。Objective It is to observe the effect of Ginkgo biloba extract combined with glucocorticoids in the treatment of idiopathic pulmonary fibrosis （IPF） and its influence on serum transforming growth factor betal （TGF-β1 ） and interleukin-13 （IL-13） , serum superoxide dismutase （SOD） , malondialdehyde （MDA） level. Methods 86 patients with IPF were randomly divided into the observation group （43 cases） and the control group （43 cases） , the patients was treated with glucoeorticoid in the control group and with Ginkgo biloba extract combined with glueocorticoids in the observation group, the course of treat- ment was 12 weeks. The changes of blood gas analysis, lung function and lung fiber index were observed before and after treat- ment in the two groups; the levels of serum TGF-β1 , IL-13, SOD and MDA were measured before and after treatment in two groups. Results The levels of p（ 02 ） and nificantly lower of the two groups after trc vation group was better than that in the co Sa（ O2 ） were significantly higher and the levels of p（ CO2 ） and P（A-a） （ O2 ） were sigatment （ all P 〈 0.05 ） , but the improvement of p（ O2 ） and P（A-a） （ O2 ） in the obserntrol group （P 〈 0.05） ; FVC, FEV1/FVC, MVV and DLCO were increased signifi- cantly in the two groups （ all P 〈 0.05 ） , the improvement of the indexes in the observation group was obviously in the control group （ all P 〈 0.05 ） ; the PC Ⅲ , C Ⅳ, PICP and LN levels were decreased obviously in the treatment （ all P 〈 0. 05 ） , the improvement of the indexes in the observation group was obviously better than group （all P 〈0.05） ; the levels of serum TGF-β 1, IL-13 and 0.05 ） , the levels of SOD were significantly higher （ P 〈 0.05 ） , better than that two groups after at in the control MDA were significantly lower in the two groups （ all P 〈 the improvement of the indexes in the observation group was better than that in the control group （P 〈 0.05）. Conclu

关 键 词：银杏叶提取物 糖皮质激素 特发性肺纤维化 转化生长因子-Β1 白细胞介素-13 超氧化物歧化酶 丙二醛 

分 类 号：R563[医药卫生—呼吸系统]