中西医结合治疗咽喉反流合并咽喉炎的临床疗效  

Effect of combination of Chinese and Western Medicine on the treatment of laryngopharyngeal reflux disease complicated with laryngopharyngitis

作　　者：魏春晖[1] 

机构地区：[1]首都医科大学附属北京友谊医院耳鼻咽喉头颈外科,北京100050

出　　处：《中国耳鼻咽喉颅底外科杂志》2017年第3期226-229,共4页Chinese Journal of Otorhinolaryngology-skull Base Surgery

摘　　要：目的探讨雷贝拉唑与多潘立酮联合中药西青果颗粒对咽喉反流(laryngo pharyngeal reflux,LPR)合并咽喉炎患者的治疗效果,及对症状缓解和生活质量的影响。方法回顾性分析2014年3月~2015年5月接受治疗的LPR合并咽喉炎患者的临床资料,根据其治疗方式分为西药组和中西药联合治疗组,西药组采用雷贝拉唑和多潘立酮治疗,中西药联合治疗组采用雷贝拉唑、多潘立酮和西青果颗粒治疗。疗程为3个月,分析两组患者的治疗效果和不良反应发生率,比较两组患者治疗前后反流症状指数量表(feflux symptom index,RSI)评分、反流检查计分量表(reflux finding score,RFS)评分和症状缓解时间的差异。结果中西药结合组治疗的有效率(97.14%)明显高于西药组(80.00%)(χ~2=5.195,P=0.023);两组患者治疗前的RSI评分无显著差异(P>0.05),治疗后中西药结合组患者的声嘶或发声问题、清喉和咽喉黏液增多等维度得分均低于西药组(P<0.05);两组患者治疗前的RFS评分无显著差异(P>0.05),治疗后中西药结合组患者的声门下水肿、喉室消失和红斑、充血等维度得分均低于西药组(P<0.05);中西药结合组患者咽部异物感、慢性咳嗽、反复清嗓和声嘶缓解时间明显短于西药组(t=30.589、12.928、8.615和9.803,P<0.001);两组肝肾功能受损、腹胀和倦怠发生率无显著差异(χ~2=0.008,P=0.930)。结论中西药结合对咽喉反流合并咽喉炎有较好的疗效,可明显改善临床症状和体征,降低不良反应发生率,具有临床应用价值。Objective To explore the effect of combination of rabeprazole, domperidone and Xiqingguo granule for the treatment of laryngopharyngeal reflux （LPR） complicated with laryngopharyngitis. Methods The clinical data of 75 patients with LPR complicated with pharyngitis treated in our hospital from March 2014 to May 2015 were analyzed retrospectively. According to the treatment methods, the patients were divided into western medicine treatment group （ n = 40） and combined treatment group （n = 35）. To the patients of the western medicine treatment group, rabeprazole and domperidone were administrated orally. For those of the combined treatment group, Xiqingguo granule （a traditional Chinese medicine preparation） was administrated in addition with rabeprazole and domperidone. The course of treatment was 3 months for both groups. Their therapeutic effects were evaluated and the incidences of adverse reactions were analyzed. The differences of reduction in reflux symptom index （RSI） , reflux finding score （RFS） and symptom alleviating time between the two groups were compared. Results The effective rate of the combined treatment group was 97.14% , which was significantly higher than that of the western medicine treatment group （ 80.00% ） （χ^2 = 5. 195, P = 0. 023 ）. The difference of RSI before treatment between the two groups was statistically insignificant （ P 〉 0.05 ）. After treatment, the scores of hoarseness or vocal problems, clearing throat and excess throat mucus of the combination treatment group were lower than those of the western medicine treatment group （ all P 〈 0.05 ）. The difference of RFS before treatment between the two groups was also statistically insignificant （P 〉 0.05）. After treatment, the scores of subglottic edema, ventricular obliteration, erythema and hyperemia of the combination treatment group were lower than those of the western medicine treatment group （ all P 〈 0.05）. The symptom alleviating time for globus sensation, chronic cough, c

关 键 词：咽喉食管 反流咽喉炎 中西药结合 反流症状指数评分量表 反流体征评分量表 

分 类 号：R766.5[医药卫生—耳鼻咽喉科]