玛咖提取物对大鼠耐力和血抗氧化酶活性的影响  

Effect of the Maca Extract on Endurance and Blood Antioxidant Enzyme Activity of Rats

作　　者：俞发荣[1] 杨博[1] 李作平[1] 连秀珍[1] 谢明仁[1] 李登楼[1] 郭蕴萱 陈望军[1] YU Farong YANG Bo LI Zuoping LIAN Xiuzhen XIE Mingren LI Denglou GUO Yunxuan CHEN Wangjun(Gansu Institute of Political Science and Law, Key Laboratory of Evidence of Science and Technology Research and Application, Lanzhou 730070, Chin)

机构地区：[1]甘肃政法学院,甘肃省证据科学技术研究与应用重点实验室,兰州730070

出　　处：《中国现代应用药学》2017年第6期824-826,共3页Chinese Journal of Modern Applied Pharmacy

基　　金：甘肃省基础研究创新群体项目(145RJIA333);兰州市科技计划项目(2014-1-182,2015-3-96);兰州市人才创新创业项目;甘肃省高校科技创新团队项目(2016C-09);西北民族地区侦查理论与实务研究中心项目;甘肃政法学院重大项目(2016XZD15)

摘　　要：目的探讨玛咖提取物对大鼠耐力和血抗氧化酶活性的影响。方法采用循环水流自由游泳和/或给予大鼠8.0,16.0,32.0 g·kg-1玛咖提取物,连续给药15 d,第16天测定耐力和血丙二醛(malondialdehyde,MDA)、超氧化物歧化酶(superoxide dismutase,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-Px)水平。结果与单纯游泳组相比,给予玛咖提取物8.0,16.0,32.0 g·kg^(-1) 15 d,下沉前游泳时间和游泳总时间分别延长了34.38%、84.25%、126.07%(P<0.01)和37.42%、47.03、107.24%(P<0.01),大鼠下沉次数分别减少了17.65%、33.28%、55.50%(P<0.01或P<0.05),MDA水平分别降低了34.63%、54.13%、63.73%(P<0.01),SOD和GSH-Px水平分别升高了67.78%,108.25%、154.49%和48.57%、110.28%、154.86%(P<0.01)。结论玛咖提取物具有抵抗疲劳,增强运动能力的作用。其机制与降低血MDA水平,提高血SOD和GSH-Px活性作用有关。OBJECTIVE To study the Maca extract on endurance of rats and the effect of blood antioxidant enzyme activity. METHODS The Wistar rats treated with/without the Maca extract（8.0, 16.0, 32.0 g·kg^（-1）） were freely swimming in the circulating water flow daily for 15 d. On the 16 th day of experiment, the blood was collected. The endurance, blood malondialdehyde（MDA）, superoxide dismutase（SOD）, glutathione peroxidase（GSH-Px） level were determinated. RESULTS Compared with those swimming rats without extract treatment, when rats were administered with Maca extract at the doses of 8.0, 16.0, 32.0 g·kg^（-1）, the swimming time before sinking and the total swimming time were increased by 34.38%, 84.25%, 126.07%（P〈0.01） and 37.42%, 47.03%, 107.24%（P〈0.01）, respectively. The times of sinking was decreased by 17.65%, 33.28%, 55.50%（P〈0.01 or P〈0.05）, respectively. The MDA content in the blood of the rats treated with 8.0, 16.0, 32.0 g·kg-1 was reduced by 34.63%, 54.13%, 63.73% respectively（P〈0.01）, while the levels of SOD and GSH-Px were enhanced by 67.78%, 108.25%, 154.49%（P〈0.01） and 48.57%, 110.28%, 154.86%（P〈0.01）, over those of rats without treatment, respectively. CONCLUSION The maca extract has resist fatigue, enhance exercise capacity effect. The mechanism is associated with reduced blood MDA, improve the activity of SOD and GSH-Px.

关 键 词：玛咖提取物 耐力 抗氧化酶 WISTAR大鼠 

分 类 号：R965.2[医药卫生—药理学]