液体复苏对严重脓毒症和脓毒症休克患者生存率的影响  

Effect of fluid resuscitation on the survival rate in patients with severe sepsis and septic shock

作　　者：张延威[1] 赵麦良[1] 陈丽霞[1] 高辉[1] 张圣[1] 王军辉[1] 赵星[1] 李超[1] 

机构地区：[1]河北省邢台市人民医院急诊科,054000

出　　处：《临床合理用药杂志》2017年第19期44-45,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的观察液体复苏对严重脓毒症和脓毒症休克患者的影响。方法将符合纳入标准的41例脓毒症患者分为2组,试验组18例使用液体复苏,对照组23例不使用液体复苏。比较2组患者的28 d生存率、急诊重症病房(EICU)住院时间和康复情况。结果 2组住院天数、28 d生存率、多器官功能障碍综合征(MODS)发生率、急性肾功能衰竭(ARF)发生率和辅助通气率比较差异均无统计学意义(P>0.05)。结论液体复苏作为一种常用的治疗手段,确实延长了脓毒症患者的在院生存天数,但患者28 d后生存率并未显著降低。不能得出患者的生存率和液体复苏治疗方案的采用有直接关系或者与MODS的发生率有直接关系的结论。采取液体复苏究竟能否改善严重脓毒症患者预后,还需要更多随机临床对照试验样本进一步证明。Objective To observe the effect of fluid resuscitation on the survival rate in patients with severe sepsis and septic shock. Methods The 41 sepsis patients who met the inclusion criteria were divided into two groups,the experimental group（ n = 18） used fluid resuscitation,and control group（ n = 23） did not use fluid resuscitation. The 28 days survival rate,hospitalization time in emergency intensive care unit（ EICU） and rehabilitation were compared between two groups. Results There was no significant difference between the two groups in hospital stay,28 days survival rate,multiple organ dysfunction syndrome（ MODS） rate,incidence of acute renal failure（ ARF） and assisted ventilation rate（ P〉0. 05）. Conclusion Fluid resuscitation as a common treatment,does extend the number of days in hospital survival in patients with sepsis. However,the28 days survival rate was not significantly lower in patients. So we can not draw a direct relationship between the use of or directly related to the incidence of MODS conclusions of survival in patients with fluid resuscitation and treatment programs. Taking fluid resuscitation whether we can improve the prognosis of patients with severe sepsis,need more randomized controlled clinical trials to prove the sample.

关 键 词：严重脓毒症 脓毒症休克 液体复苏 

分 类 号：R459.7[医药卫生—急诊医学]