防晒霜组方优化及评价  

Optimization and formulation of sunscreen creams

作　　者：王家典[1] 卢鋆[1] 崔淦[1] 徐俊达 邢博宇 郭思远[1] 龚慕辛[1] 

机构地区：[1]首都医科大学中医药学院,北京100069

出　　处：《中华医学美学美容杂志》2017年第3期199-202,共4页Chinese Journal of Medical Aesthetics and Cosmetology

摘　　要：目的 筛选和评价防晒霜优化配方.方法 采用正交试验设计,将一定量不同配方的防晒霜涂抹于贴有3M胶带的比色皿上,分别测定其在280～320 nm和320～400 nm之间各波长对应吸光度（A）的算术平均值,并通过比较A值大小,确定防晒效果以及影响防晒效果的主要因素,再将筛选出的优化配方用多点递增紫外辐照的方法进行人体防晒效果测试.结果 含有5种防晒剂的防晒霜处方1的长波紫外线（UVA）吸光度为1.02,中波紫外线（UVB）吸光度为3.62,防晒指数（SPF）为18左右,UVA防护指数等级PA为＋.防晒剂甲氧基肉桂酸辛酯（OMC）、天来施M、芦丁、珍珠粉、黄芩苷均具有防UVA的显著效果,OMC还具有防UVB的显著效果.结论 含5种防晒剂的处方1在UVA和UVB区均有较好的防晒效果.Objective To optimize the formulation of the sunscreen used in military training.Methods The different formulations of sunscreen were prepared according to the orthogonal design,and then applied on 3M adhesive tape posted on the color dish with a certain amount;the absorbance in 280 nm-320 nm and 320 nm-400 nm of them were measured and the arithmetic mean （A） was concluded.By comparing A,the protective effect and the main factors affecting preventive bask were determined.The preventive bask test of the optimum formula was carried out in human trials using the method of multi point increasing ultraviolet irradiation.Results OMC,TinosorbTM M,rutin,pearl powder and baicalin all had significant effects in preventing UVA.OMC had a significant effect in preventing UVB.The formula 1 （containing the five materials mentioned above） had the best effects in preventing both UVA （SPF 18） and UVB （PA＋）.Conclusions The formula 1 has the best effects in preventing both UVA and UVB.

关 键 词：防晒霜 正交试验 防晒效果 

分 类 号：TQ658.24[化学工程—精细化工]