RLRs介导的抗病毒免疫效应的研究进展  

Retinoic-acid-inducible Gene 1 Like Receptors Family Mediated Innate Antiviral Immune Reponses

作　　者：刘洋[1] 陈颂[1] 葛金文[1] 朱惠斌[1] 

机构地区：[1]湖南中医药大学中西医结合学院,长沙410208

出　　处：《医学综述》2017年第12期2298-2302,2307,共6页Medical Recapitulate

基　　金：国家自然科学基金(81573822)

摘　　要：视黄酸诱导基因1样受体家族(RLRs)是天然免疫系统中重要的病原模式识别受体,在抗病毒免疫的过程中发挥着重要作用。其主要功能是在病毒感染过程中,识别并结合病原体相关分子模式,活化下游信号分子,扩大级联反应,诱导机体天然免疫发生,控制病毒的早期复制与传播,构建机体免疫防御城墙。同时,RLRs及其信号产物还可以参与机体对适应性免疫的调控,影响病毒特异性细胞毒T淋巴细胞的形成,以及在机体对抗持续性病毒感染过程中发挥一定的作用。Retinoic-acid-inducible gene 1 like receptors（ RLRs）,an important pathogen pattern recognition receptor family of innate immune system,play a key role in innate immunity and homeostasis. The major function of RLRs is to recognize pathogen-associated molecular patterns during viral infection,thereby activate downstream signaling molecules,expand cascade reactions and induce antivirus innate immune responses to contain viral replication and transmission,thus build the body＇s immune defense walls. In addition,RLRs and its signal products can also regulate adaptive immunity during infection,such as the function of T cells and their subsets,as well as playing a certain role in the body against persistent viral infection process.

关 键 词：天然免疫 适应性免疫 视黄酸诱导基因1样受体家族 

分 类 号：R392.1[医药卫生—免疫学]