脂肪因子基因多态性与冠状动脉粥样硬化的研究进展  

Research Progress of Adipokines Gene Polymorphism and Atherosclerosis of Coronary Artery

作　　者：张守信[1] 孙成铭[1] 杨军[1] 

机构地区：[1]青岛大学附属烟台毓璜顶医院生物芯片实验室,山东烟台264000

出　　处：《医学综述》2017年第12期2308-2312,2317,共6页Medical Recapitulate

基　　金：烟台市科学技术发展计划(第二批)(2013WS224)

摘　　要：脂肪因子由脂肪组织分泌,其不仅参与维持机体能量稳态和调控糖、脂代谢平衡,还直接或间接参与动脉粥样硬化的病理生理过程,在冠心病的发生、发展中起重要作用。随着分子生物学的快速发展及人类基因组计划的进行,从基因水平阐明冠心病的发病机制成为医学研究的热点。而探讨不同种族和地区人群中脂联素、抵抗素、内脂素、血清淀粉样蛋白A等脂肪因子基因单核苷酸多态性分布情况,及其与冠状动脉粥样硬化的关系,对冠心病高风险人群和患者的早期预防和治疗具有重要意义。故未来应积极开展脂肪因子相关基因型检测,分析基因单核苷酸多态性与冠状动脉粥样硬化遗传易患性的相关性,可能为冠心病的预防和诊疗提供新手段。The adipokines are secreted by adipose tissue,which maintain the energy steady state,regulate the balance of glucose and lipid metabolic,and play an important role in the occurrence and development of coronary heart disease,directly or indirectly involved in the pathophysiological process of atherosclerosis. With the rapid development of molecular biology and the human genome project,the pathogenesis of coronary heart disease is clarified from the gene level,and now it is becoming a hot spot in the medical research field. Exploration of the distribution of single nucleotide polymorphisms of adipokines genes including adiponectin,resistin,visfatin and serum amyloid A and the relationship between these single nucleotide polymorphisms and coronary atherosclerosis for populations in different ethnic and geographic groups,is of great significance to improve the prevention and treatment of coronary heart disease. Therefore,the genotype detections for adipocytokines and the analysis of the correlation between gene single nucleotide polymorphisms with genetic susceptibility of coronary atherosclerosis actively in future,may provide new measures to prevent,diagnose,and treat coronary heart disease.

关 键 词：冠状动脉粥样硬化 脂肪因子 基因多态性 

分 类 号：R541.4[医药卫生—心血管疾病]