血清甘胆酸在新生儿溶血性黄疸中的临床价值  

Clinical application value of serum cholyglycine in neonatal hemolytic jaundice

作　　者：陈丽萍[1] 陈媛[1] 黄晓华[1] 吴定昌[1] 

机构地区：[1]福建省龙岩市第一医院/福建医科大学附属龙岩第一医院检验科,龙岩364000

出　　处：《右江民族医学院学报》2017年第3期168-171,共4页Journal of Youjiang Medical University for Nationalities

摘　　要：目的探讨血清甘胆酸(cholyglycine,CG)在新生儿溶血性黄疸中的临床价值。方法选取新生黄疸患儿124例(包括溶血性黄疸组37例、感染性黄疸组46例、生理性黄疸组41例)和健康新生儿60例(对照组)作为研究对象。采用均相免疫法检测各组血清CG水平,同时检测总胆汁酸(TBA)、总胆红素(TBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、谷氨酰转肽酶(GGT)等生化指标,并进行相关性和受试者工作曲线(ROC)分析。结果三个病患组与健康对照组相比,各指标均显著增高(P均<0.001);其中溶血性黄疸和感染性黄疸组血清CG、TBIL水平均显著高于生理性黄疸组(P<0.05),而溶血性黄疸组与感染性黄疸组相比,各指标均差异无统计学意义(P均>0.05)。CG与TBA成正相关(r=0.764,P<0.001);溶血性黄疸组分别以生理性黄疸和健康新生儿为对照,其CG曲线下面积为0.711和0.995,均明显高于TBA、ALT、AST、GGT指标;且其敏感性也高于其他指标。结论血清CG是新生儿溶血性黄疸和生理性黄疸的鉴别诊断评价指标之一,其在新生儿肝功能损伤中的诊断效能优于TBA、ALT等肝功能指标。Objective To molytic jaundice. Methods investigate clinical application value of serum cholyglycine（CG） in neonatal he A total of 124 newborns with jaundice （including 37 neonatal hemolytic jaun dice, 46 infectious jaundice, 41 physiologic jaundice） and 60 healthy newborns as controls were recruited. We detected serum CG levels of every group with homogeneous immunity method, at the same time we measured the levels biological indexes, such as total bile acid （TBA）, total bilirubin （TBIL）, alanine transaminase （ALT）, aspartate aminofransferase （AST）, glutamate transpeptidase （GGT）, etc.. Then, the correlation and receiver operating characteristics curve （ROC） were analyzed. Results CG, TBA, TBIL, ALT, AST and GGT levels were significantly higher in three patient groups than those of healthy controls （all P %0. 001）. Levels of CG and TBIL were also significantly higher in neonatal hemolytic jaundice and infectious jaundice groups than physiological jaundice group （ P %0.05）. However, comparing the six indexes between neonatal hemolytic and infectious jaundice groups yielded no statistical differences （all P 〉0.05）. CG had positive correlation with TBA （ r =0. 764, P %0. 001）. Compared hemolytic jaundice group to physiological jaundice group and healthy newborns, the area under curve （AUC） of CG was 0. 711 and 0. 955, respectively, which were sig- nificantly higher than those of TBA, ALT, AST and GGT indicators. And the sensitivity of CG was also higher than those of other indicators. Conclusion Serum CG could be one of the differential di agnostic evaluation biomarkers for neonatal hemolytic jaundice and physiological jaundice. The diagnostic efficacy of CG was superior to other liver function indexes （TBA, ALT, etc. ） in evaluation of neonatal liver function damage.

关 键 词：甘胆酸 新生儿溶血性黄疸 肝功能受损 应用价值 

分 类 号：R442.4[医药卫生—诊断学]