急性颅脑创伤患者血浆FⅦ活性变化及其与凝血功能相关性  

Correlation Analysis of Activity of F Ⅶ and Coagulation Function in Patients with TraumaticBrain Injury

作　　者：孙秀海 代学良[1] 刘洪义[1] 

机构地区：[1]山东省邹城市人民医院神经外科,山东邹城273500

出　　处：《医学临床研究》2017年第6期1096-1098,共3页Journal of Clinical Research

摘　　要：【目的】探讨急性颅脑创伤患者血浆凝血因子Ⅶ（FⅦ）活性变化及其与凝血功能的相关性。【方法】选取2014年3月至2016年3月本院收治的急性颅脑创伤患者92例作为观察组，同时选择同期在本院体检健康的92例健康志愿者作为对照组，检测两组血浆FⅦ活性值，并检测活化部分凝血活酶时间（AFFF）、血小板（PLT）、D-二聚体、纤维蛋白原（FIB）、血红蛋白（Hb）、血乳酸（Lac）等相关凝血指标，计算国际标准化比值（INR），并检测颅内压（ICP）。比较观察组和对照组血浆FⅦ活性及其与凝血功能指标的相关性。【结果】观察组血浆FⅦ活性值为（91．45±32．10）％，对照组为（97．20±16．03）％，两组比较差异无统计学意义（t=-1．537，P〉0．05）。血浆FⅦ活性低患者INR、APTT、Lac显著高于血浆FⅦ活性高的患者，血浆FIB水平显著低于血浆FⅦ活性高者，差异均具有统计学意义（均P〈O．05）。观察组伴凝血功能异常患者共计35例，其血浆FⅦ活性为（86．70±28．84）％，观察组不伴凝血功能异常患者57例，其血浆FⅦ活性为（97．83±30．16）％，两组比较差异具有统计学意义（t=-2．176，P〈0．05）。【结论】急性颅脑创伤患者血浆FⅦ活性与凝血功能有一定联系，凝血功能异常患者血浆FⅦ活性有所降低，值得临床进一步研究。[Objective]To investigate the plasma coagulation factor Ⅶ activity and its correlation with blood coagulation function in patients with acute craniocerebral trauma.[Methods]Ninety-two patients with a- cute craniocerebral trauma treated in our hospital from March 2014 to March 2016 were selected as the obser- vation group, At the same time, 92 healthy volunteers in our hospital for the same period were selected as the control group, FⅦ activity value, the activated partial thromboplastin time （AFFF）, platelet （PLT）, two D- dimer, fib rinogen （FIB）, hemoglobin （Hb）, blood lactate （Lac） and other related blood coagulation index, were detected in the two groups. The international normalized ratio （INR） was calculated and intracranial pres- sure （ICP） was measured. The correlation between the observation group and the control group plasma FⅦ activity and its coagulation indexes were compared.[Results]FⅦ activity value of plasma of the observation group was （91.45±32.10） %, that of the control group was （97.20±16.03） %, two groups had no statistically significant difference （ t = -1.537,P 〉0.05）.INR, APTT and Lac were significantly higher than that of plas- ma F activity in patients with high plasma activity FⅦ. The plasma FIB level was significantly lower than that of plasma F VH high activity, the differences were statistically significant （P 〈0.05）, abnormal coagulation function in patients of the observation group counted a total of 35 cases, the plasma activity of FⅦ was （86.70 ±28.84）%, 57 patients was accompanied with coagulation dysfunction in the observation group, The plasma activity of F Ⅶ was （97.83±30.16）%, there were significant differences between the two groups （t = -2.176, P 〈0.05）.[Conclusion]Plasma activity FⅦ in patients with acute craniocerebral trauma is related to coagulation function, Plasma activities FⅦ in patients with abnormal coagulation function decreased, which is worthy of further clinical research.

关 键 词：颅脑损伤 急性病 因子Ⅶ 血液凝固 

分 类 号：R651.15[医药卫生—外科学]