多胺代谢与缺血性心血管疾病研究进展  

Review on the Research Progress of Polyamines Metabolism and Ischemic Cardiovascular Disease

作　　者：任婷[1] 成细华[1] 陈聪[1] 吴若霞[1] 饶春梅[1] 彭霞[1] 孙彦波[1] 黄政德[1] 

机构地区：[1]湖南中医药大学,湖南长沙410208

出　　处：《湖南中医药大学学报》2017年第6期690-692,共3页Journal of Hunan University of Chinese Medicine

基　　金：国家自然科学基金资助项目(81373576;81503536);湖南省教育厅项目(14B136;14C0872);湖南省中医药管理局重点课题(201304);湖南省科技厅一般项目(2014SK3034);中西医结合防治心脑疾病的相关基础研究湖南省高校科技创新团队科研项目(5)

摘　　要：多胺广泛分布于生物组织和体液中,参与体内多种生理和病理过程,具有促进细胞生长、分化、增生,对维持细胞膜和线粒体的完整性,DNA和RNA结构的稳定性,以及在信号转导、基因表达、蛋白合成等方面都意义重大。多胺参与心肌缺血损伤的发生,多胺代谢失衡,鸟氨酸脱羧酶及精脒/精胺乙酰转移酶活性改变,腐胺生成增多而精胺、精脒减少,将导致继发性的心肌损伤,本文就多胺及多胺在缺血性心血管疾病研究中的意义及进展加以综述。Polyamine, involved in a variety of physiological and pathological process in the body, is widely distributed in biological tissues and fluids, which can promote cell growth, differentiation, hyperplasia. They show great significance in maintaining the integrity of the cell membrane and mitochondria, stability of DNA and RNA structure, and in signal trans-duction, gene expression, protein synthesis. Polyamine participates in the occur of myocardial ischemia injury. The imbalance of polyamine metabolism, changes of ornithine decarboxylase and spermidine/spermine N 1-acetyltransferase activities, increased formation of putrescine, decreased spermine and spermidine, will lead to secondary myocardial injury. In this paper, the polyamine and its significance and the progress in the study of ischemic cardiovascular diseases are reviewed.

关 键 词：多胺 ODC SSAT 心肌缺血 

分 类 号：R541[医药卫生—心血管疾病]