乌司他丁对老年胆石病围术期炎症反应及肝功能的影响  

The Effect of Ulinastatin on Inflammatory Response and Liver Function in Elderly Patients With Cholelithiasis

作　　者：李昌[1] 韩冰[1] 蓝诺[2] 

机构地区：[1]山东省单县中心医院普一科,山东菏泽274300 [2]山东省单县中心医院麻醉科,山东菏泽274300

出　　处：《中国继续医学教育》2017年第13期152-153,共2页China Continuing Medical Education

摘　　要：目的探讨乌司他丁对老年胆石病患者围术期炎症因子释放及肝功能的影响。方法 40例拟行手术的老年胆石病患者随机分为治疗组和对照组,治疗组于术后5天内在常规方法上加用乌司他丁20万U,对照组按常规加用同等剂量的生理盐水,分别于术前和术后第1、3、5天抽取外周静脉血,检测血清ALT、AST、TBIL、CRP、TNF-α及IL-6水平。结果对照组血清TNF-α、IL-6、CRP水平在术后1天、3天、5天均高于治疗组,差异具有统计学意义(P<0.05);对照组血清ALT、AST、TBIL水平在术后1天、3天均高于同期治疗组,差异具有统计学意义(P<0.05)。结论乌司他丁可减轻老年胆石病患者围术期细胞炎症因子介导的炎症反应,保护肝脏功能。Objective To investigate the protective effects of ulinastatin on inflammatory response and the liver function in elderly cholelithiasis combined patients during perioperative period. Methods 40 cases of patients underwent cholelithiasis combined were randomly divided into control group and therapeutic group, the ulinastatin of 0.2 million units was used by drip in the therapeutic group in the postoperative 1, 3, 5 days. The control group was only as the same amount of normal saline, the level of ALT, AST, TBIL, CRP, TNF-α and IL-6 were determined during before operation and postoperative 1, 3, 5 days respectively. Results The TNF-α, IL-6, CRP level in control group were significantly higher than therapeutic group at 1st, 3rd and 5th day（P〈0.05）. The ALT, AST, TBIL level in control group were significantly higher than in therapeutic group at 1st and 3rd day（P〈0.05）. Conclusion Ulinastatincan, down regulate inflammation and protect liver function in elderly cholelithiasis combined patients.

关 键 词：乌司他丁 胆石病 炎症因子 

分 类 号：R657[医药卫生—外科学]