头孢呲肟与头孢噻肟治疗老年细菌性下呼吸道感染的随机对比研究  

A clinical trial of the therapeutic effect of cefepime in aged patients with bacterial lower-respiratory infection

作　　者：包云[1] 申彤蕾[1] 蒋有娟[1] 董根妹[1] 袁粉定[1] 

机构地区：[1]扬州市第一人民医院,扬州225001

出　　处：《中国抗生素杂志》2002年第6期351-353,共3页Chinese Journal of Antibiotics

摘　　要：目的 :评价头孢吡肟治疗老年细菌性下呼吸道感染的临床疗效和安全性。方法 :将 68例老年细菌性下呼吸道感染患者随机分为试验组和对照组 ,分别给头孢吡肟静滴 1g ,每日二次或头孢噻肟静滴 2g ,每日二次 ,疗程均为 7～ 10d。结果 :两组痊愈率分别为 5 8.8%和 2 6.5 %,总有效率分别为 91.2 %和 67.6%;治疗后细菌清除率分别为 89.7%和 63 .3 %;以上结果均有显著性差异。不良反应发生率分别为 5 .9%和 8.8%,两组比较无显著性差异。结论 :头孢吡肟抗菌谱广 ,疗效好 ,不良反应轻微 ,对治疗老年细菌性下呼吸道感染是一个安全。Object: To evaluate the efficacy and safety of cefepime in aged patients with bacterial lower respiratory infections. Methed: Sixty eight aged patients and control group. Patients of test group were treated with cefepime and control group with bacterial lower respiratory infections were randomly divided into test group with cefotaxime. Resuts: The overall effective rates of cefepime and cefotaxime treatment groups were 91.2%(30/34) and 67.6%(23/34); and bacterial clearance rates were 89.1%(26/29) and 63.3%(19/30) respectively. There was a statistcal significance between the two groups ( P <0.05). Adverse drug event rates of two groups were 5.9%(2/34) and 8.8%(3/34) respectively, no significant difference was noted between cefepime and cefotaxime groups. Conclusion: Cefepime has a good therapeutic efficacy and safety in the treatment of aged patients with bacterial lower respiratory infections.

关 键 词：头孢呲肟 头孢噻肟 随机对比研究 老年患者 细菌性下呼吸道感染 疗效 安全性 

分 类 号：R560.5[医药卫生—呼吸系统] R978.11[医药卫生—内科学]