肿瘤标志物CA72-4对胃癌患者预后影响的系统评价  

Meta-analysis of prognostic value of carbohydrate antigen 72-4 in patients with gastric cancer

作　　者：李立辉[1] LI Lihui(Department of Clinical Blood, Liaoning Clinical Laboratory Center, Shenyang, Liaoning 110016, China)

机构地区：[1]辽宁省临床检验中心临床血液室,沈阳110016

出　　处：《检验医学与临床》2017年第13期1873-1876,共4页Laboratory Medicine and Clinic

摘　　要：目的系统评价肿瘤标志物糖类抗原(CA)72-4对胃癌患者的预后影响。方法使用计算机系统地检索PubMed和Embase数据库关于CA72-4和胃癌预后的文献,文献检索日期截止至2014年7月。除了进行总的Meta分析,同时还进行合适的敏感性分析和亚组分析。结果本研究共纳入符合纳入标准的文章13篇,共计4 604例胃癌患者。与CA72-4正常的胃癌患者比较,CA72-4阳性患者的总生存率(HR=1.49,95%CI 1.25~1.77,P<0.01)和无病生存率差(HR=2.26,95%CI 1.54~3.30),差异有统计学意义(P<0.01)。结论 Meta分析提示胃癌患者肿瘤标志物CA72-4水平与预后相关,可作为重要的预后影响因素。Objective The aim of our meta-analysis is to assess the prognostic value of carbohydrate antigen 72-4（CA72-4） in patients with gastric cancer. Methods PubMed,Embase,and the references in relevant studies were systematically searched（up to July,2014）. Besides overall analysis,subgroup and sensitivity analyses were also performed. Results Thirteen eligible studies were analyzed,containing 4 604 patients with gastric cancer. CA72-4 level was significantly inversely associated with the overall survival （OS,HR=1. 49,95%CI 1.25-1.77,P〈0. 001） and disease-free survival（DFS,HR= 2.26,95%CI 1.54-3.30,P〈0.01）. Conclusion Our meta-anaiysis indicates that CA72-4 level is inversely associated with the prognosis for gastric cancer and may play an important prognostic factor for patients with gastric cancer.

关 键 词：糖类抗原72-4 肿瘤标志物 胃癌 预后 

分 类 号：R735.204[医药卫生—肿瘤]