六味地黄丸配合降糖药降糖效果及降低低血糖风险的临床评价  

Hypoglycemic effect of Liuwei Dihuang pills combined with hypoglycemic drugs and clinical evaluation on reducing the risk of hypoglycemia

作　　者：湛献能[1] 黄美凌[1] 冯崇廉[1] 

机构地区：[1]广州医科大学附属第三医院,510150

出　　处：《国际医药卫生导报》2017年第14期2160-2162,共3页International Medicine and Health Guidance News

基　　金：广东省中医药局基金项目（20142099）

摘　　要：目的六味地黄丸在中西医联合用药临床治疗2型糖尿病时的降糖效果及降低低血糖发生风险的作用。方法本研究208例2型糖尿病患者随机分为观察组与对照组，其中观察组采用六味地黄丸配合二甲双胍治疗，对照组采用二甲双胍治疗。16周后观察FBG、2hPBG、HbAIC、低血糖等情况。结果两组患者治疗后FBG、2hPBG差异均有统计学意义（f=5．67，6．32；P〈0．01）；两组总体降糖疗效比较，观察组优于对照组（Z=4．187，P〈0．05）；治疗后观察组低血糖发生次数少于对照组（x2=7．61。P〈0．05）。结论六味地黄丸配合二甲双胍治疗2型糖尿病，可获得较佳的临床疗效及降低低血糖风险，在临床上值得推广应用。Objective To study the hypoglycemic effect of Liuwei Dihuang pills combined with bypoglycemic drugs and clinical evaluation on reducing the risk of hypoglycemia in the treatment of type 2 diabetes mellitus. Methods A total of 208 patients with type 2 diabetes mellitus were randomly divided into the observation group and the control group. The observation group was treated with Liuwei Dihuang pills combined with metformin, while the control group was treated with metformin. After 16 weeks, FBG, 2hPBG, HbA1C, hypoglycemia and so on were observed. Results There were statistically significant differences in FBG, 2hPBG between the two groups after treatment （t=5.67, 6.32; P〈0.01）; the overall hypoglycemic effect of the observation group was better than that of the control group （Z=4.187, P〈0.05）; the incidence of hypoglycemia in the observation group was lower than that in the control group after treatment （X 2=7.61, P〈0.05）. Conclusion Liuwei Dihuang pills combined with metformin in the treatment of type 2 diabetes mellitus can obtain better clinical efficacy and reduce the risk of hypoglycemia, worthy of clinical application.

关 键 词：六味地黄丸 降糖 低血糖 

分 类 号：R587.1[医药卫生—内分泌]