致病细菌诱发细胞焦亡研究进展  

Progress on Pyroptosis Induced by Pathogenic Bacteria

作　　者：卫朝辉 刘超英[1] 高飞龙[1] 王世玉[1] 严玉霖[1] 高洪[1] 

机构地区：[1]云南农业大学动物科学科技学院,云南昆明650201

出　　处：《动物医学进展》2017年第7期78-82,共5页Progress In Veterinary Medicine

基　　金：国家自然科学基金项目(31260594;31660704);云南省高校科技创新团队支持计划资助项目(云教科[2011]14号);云南省现代农业生猪产业技术体系建设项目(云财农[2009]171号)

摘　　要：细胞焦亡(pyroptosis)是一种新发现的促炎性细胞程序性死亡方式。炎性小体和半胱天冬酶在细胞焦亡发生的过程中起着重要作用。细胞焦亡主要依赖半胱天冬酶1(caspase-1)、半胱天冬酶4(caspase-4)、半胱天冬酶5(caspase-5)及半胱天冬酶11(caspase-11)也可以介导。致病细菌刺激细胞内模式识别受体激活炎性小体形成,依赖于caspase-1的经典焦亡途径和依赖于caspase-4、caspase-5、caspase-11的非经典焦亡途径启动诱发细胞焦亡。细胞焦亡的形态特征以发生机理与凋亡、坏死存在着差异。论文主要对细胞焦亡的形态学特征、发生机制及致病细菌诱发的焦亡进行综述,以期为进一步研究细胞焦亡提供理论基础。Pyroptosis is a new form of programmed cell death activated by inflammatory caspases.Inflammasome and caspase protein family play important roles in process of pyroptosis.Pyroptosis mainly depends on caspase-1 activation, and caspase-4, caspase-5, caspase-11 can also mediate it.Pathogenic bacteria stimu- late intracellular pattern recognition receptor, and can promote the formation of inflammasome, canonical pyroptosis depending on caspase-1 and non-canonical pyroptosis depending on caspase-4, caspase-5, caspase- 11 start to mediate pyroptosis.The morphologic characteristics and molecular mechanisms of pyroptosis are distinct from those of apoptosis or necrosis.This paper summarized the morphologic characteristics, molecular mechanisms of pyroptosis and pathogenic bacteria inducing pyroptosis in order to provide a theoretical basis for further understanding of pyroptosis.

关 键 词：细胞焦亡 致病细菌 炎性小体 半胱天冬酶 

分 类 号：S852.33[农业科学—基础兽医学]