Serum Fetuin-A Levels and Thyroid Function in Middle-aged and Elderly Chinese  

作　　者：DENG Xin Ru DING Lin WANG Tian Ge XU Min LU Jie Li LI Mian ZHAO Zhi Yun CHEN Yu Hong BI Yu Fang XU Yi Ping XU Yu 

机构地区：[1]State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine,and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China [2]Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China [3]Department of Research and Development, Rui-Jin Hospital,Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China

出　　处：《Biomedical and Environmental Sciences》2017年第6期455-459,共5页生物医学与环境科学（英文版）

基　　金：supported by grants 2015CB553601 from the National Basic Research Program of China(973 Program);201502007 from the Ministry of Health;2015BAI12B14 from the Ministry of Science and Technology;81622011,81321001,81390350,81130016,and 81561128019 from the National Natural Science Foundation of China;supported by the Pujiang Talent Program(15PJD027)from the Science and Technology Commission of Shanghai Municipality;the Gaofeng Gaoyuan Program for Clinical Scientists(20161307)from Shanghai Jiao-Tong University School of Medicine

摘　　要：Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis revealed that serum fetuin-A concentra- tions were positively associated with log （free triiodothyronine） and were inversely associated with log （thyroid peroxidase antibody） after adjustment （both P 〈 0.05）. Compared with the participants in the lowest tertile of free triiodo- thyronine and free thyroxine level, those in the highest tertile had higher fetuin-A concentrations. Additionally, high serum fetuin-A concentrations were related to high thyroid function （odds ratio 1.27, 95% confidence interval 1.01-1.61）, after adjustment for conventional risk factors.Serum fetuin-A levels are reportedly elevated in hyperthyroidism. However, there are few relevant epidemiologic studies. We conducted a cross-sectional study in Songnan community, China in 2009 to investigate the association between serum fetuin-A concentrations and thyroid function. A total of 2,984 participants aged 40 years and older were analyzed. Multivariable linear regression analysis revealed that serum fetuin-A concentra- tions were positively associated with log （free triiodothyronine） and were inversely associated with log （thyroid peroxidase antibody） after adjustment （both P 〈 0.05）. Compared with the participants in the lowest tertile of free triiodo- thyronine and free thyroxine level, those in the highest tertile had higher fetuin-A concentrations. Additionally, high serum fetuin-A concentrations were related to high thyroid function （odds ratio 1.27, 95% confidence interval 1.01-1.61）, after adjustment for conventional risk factors.

分 类 号：R581[医药卫生—内分泌]