滋肾清肝方对原发性高血压患者动脉功能及炎症因子的影响  

Effects of Zishen Qinggan Formula on Arterial Function and Inflammatory Factors in Patients with Essential Hypertension

作　　者：李一卓[1] 黄辉[1] 顾万建[1] 刘牛[1] 季明德[1] 吴林琳 栾云[1] 严士海[1] 刘福明[1] LI Yi-zhuo HUANG Hui GU Wan-jian LIU Niu JI Ming-de WU Lin-lin LUAN Yun YAN Shi-hai LIU Fu-ming(Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, 210029, China)

机构地区：[1]南京中医药大学附属医院,江苏南京210029

出　　处：《南京中医药大学学报》2017年第4期344-348,共5页Journal of Nanjing University of Traditional Chinese Medicine

基　　金：江苏省自然科学基金(BK20151355)

摘　　要：目的通过观察滋肾清肝方对原发性高血压患者动脉功能及血清炎症因子的影响,评价滋肾清肝方的临床疗效。方法选择符合纳入标准的原发性高血压患者100例,随机分为治疗组及对照组各50例,治疗组予ACEI/ARB+CCB类药物标准治疗基础上联用滋肾清肝方,对照组予ACEI/ARB+CCB类药物,疗程为8周,对比患者治疗前后中医证候积分、颈动脉内膜中层厚度、极速成像脉搏波传导速度、阻力指数、炎症因子、安全性指标的变化。结果 (1)2组中医证候积分治疗后均有改善(P<0.01),且治疗组优于对照组(P<0.01);(2)双侧颈动脉极速脉搏波传导速度、阻力指数(RI)2组治疗后均有改善(P<0.01),其中治疗组优于对照组(P<0.05),双侧颈动脉内膜中层厚度(IMT)2组治疗前后无明显差异(P>0.05);(3)2组治疗后血清CRP、IL-6、TNF-α水平均有改善(P<0.05),治疗组优于对照组(P<0.05);(4)2组治疗前后肝肾功能均无统计学意义(P>0.05)。结论西药ACEI/ARB+CCB基础治疗联合滋肾清肝方对原发性高血压患者动脉弹性功能及炎症因子的改善优于单用ACEI/ARB+CCB基础治疗。OBJECTIVE To evaluate the clinical efficacy of Zishen Qinggan Formula through observing its effects on arterial function and inflammatory factors in patients with essential hypertension. METHODS 100 essential hypertension patients who meet the inclusion criteria were selected and randomly divided into the treatment group and the control group, 50 cases in each group. The treatment group received ACEI/ARB＋CCB standard treatment combined with Zishen Qinggan Formula, and the control group received ACEI/ARB＋CCB drugs treatment. The course of treatment was 8 weeks. Changes of TCM syndrome scores, carotid intima-media thickness, UltraFast imaging pulse wave velocity （PWV）, resistance index, inflammatory factors and safety indexes were compared before and after treatment. RESULTS ①TCM syndrome scores in both groups improved significantly after treatment, and that in the treatment group was better than the control group（P〈0.01）. ② UltraFast ima- ging PWV of bilateral carotid arteries and resistance indexes in both groups improved after treatment （P〈0.01）, among which the treatment group was better than the control group（P 〈0.05）. IMT of bilateral carotid arteries had no difference in two groups before and after treatment （P〉0.05）. ③ Levels of serum CRP, IL6 and TNFa in both group improved after treatment （P〈0.05）, and that in the treatment group were better than the control group（P〈0.01） @ There was no significant differ- ence in liver and kidney function in two groups before and after treatment （P〉0.05）. CONCLUSION In the aspect of im provement of arterial elasticity and inflammatory factors in patients with essential hypertension, western medicine ACEI/ARB＋CCB basic therapy combined with Zishen Qinggan Formula is better than ACEI/ARB＋CCB basic therapy alone.

关 键 词：滋肾清肝方 原发性高血压 动脉功能 炎症因子 

分 类 号：R259[医药卫生—中西医结合]