N-methylation of quinolines with CO2 and H2 catalyzed by Ru-triphos complexes  

作　　者：Zhenhong He Huizhen Liu Qingli Qian Lu Lu Weiwei Guo Lujun Zhang Buxing Han 

机构地区：[1]Beijing National Laboratory for Molecular Sciences,CAS Key Laboratory of Colloid and Interface and Thermodynamics,Institute of Chemistry,Chinese Academy of Sciences,Beijing 100190,China [2]University of Chinese Academy oJSciences,Beijing 100049,China [3]College of Chemistry and Chemical Engineering,Shaanxi University of Science&Technology,Xi'an 710021,China

出　　处：《Science China Chemistry》2017年第7期927-933,共7页中国科学（化学英文版）

基　　金：supported by National Natural Science Foundation of China(21603235,21373234,21533011);Chinese Academy of Sciences(QYZDY-SSW-SLH013);the Recruitment Program of Global Youth Experts of China

摘　　要：N-methyl-tetrahydroquinolines(MTHQs) are a kind of very useful chemicals, which can be obtained from N-methylation of amines.However, the methylation of quinolines which is a kind of highly unsaturated nitrogen-containing heterocyclic aromatic compounds has not been reported. In this work, we report the first work for the synthesis of MTHQs by methylation of quinolines using CO_2 and H_2. It was found that Ru(acac)_3-triphos [triphos: 1,1,1-tris(diphenylphosphinomethyl)ethanl] complex was very active and selective for the N-methylation reaction of quinolines, and the yield of the desired product could reach 99%.N-methyl-tetrahydroquinolines（MTHQs） are a kind of very useful chemicals, which can be obtained from N-methylation of amines.However, the methylation of quinolines which is a kind of highly unsaturated nitrogen-containing heterocyclic aromatic compounds has not been reported. In this work, we report the first work for the synthesis of MTHQs by methylation of quinolines using CO2 and H2. It was found that Ru（acac）3-triphos [triphos： 1,1,1-tris（diphenylphosphinomethyl）ethanl] complex was very active and selective for the N-methylation reaction of quinolines, and the yield of the desired product could reach 99%.

关 键 词：methylation hydrogenation quinoline derivatives carbon dioxide homogeneous catalysis 

分 类 号：O626.323[理学—有机化学]