微针辅助经皮给药系统的研究进展  

Development of Micro-needle Assisted Transdermal Drug Delivery System

作　　者：沈晨[1] 夏旭[1] 高文彦[1] 曾珊珊[1] 叶金翠[1] 

机构地区：[1]浙江省医学科学院,浙江杭州310000

出　　处：《中国医药工业杂志》2017年第7期965-973,共9页Chinese Journal of Pharmaceuticals

基　　金：浙江省科技厅项目(2014F10034;2016F50016;2017C33147);浙江省卫生高层次创新人才培养工程项目

摘　　要：微针辅助药物经皮给药系统(micro-needle assisted transdermal drug delivery system,MN-assisted TDDS)是指利用微针对皮肤进行预处理,微针穿透角质层形成微孔通道,然后给予经皮给药制剂使药物通过微孔通道渗透进入皮肤的给药方式。与单独使用透皮制剂相比,微针辅助经皮给药可以明显提高药物经皮吸收的速率,并且能促进蛋白质、多肽等大分子物质以及水溶性药物的透皮吸收,因此在经皮给药系统研究领域有良好应用前景。本文从药物经皮促进机制、研究现状以及存在的瓶颈等方面对微针辅助经皮给药系统进行了综述,并展望了微针辅助经皮给药的发展前景。Micro-needle （MN） assisted transdermal drug delivery system （MN-assisted TDDS） is a combination model, in which a MN array is inserted into the skin and removed after a short time before transdermal administration. Upon removal, a drug-loaded formulation is placed on the region previously punctured by the MNs. The efficiency of drug penetration through the skin treated with MN-assisted TDDS is much higher than that of applying TDDS alone, and MN-assisted TDDS can also promote the percutaneous absorption of macromolecular drugs such as proteins, polypeptides as well as hydrophilic drugs. Because of these advantages, MN-assisted TDDS has a promising prospect of application. In this paper we have reviewed the development of MN-assisted TDDS and mainly discussed its penetration mechanism, preparation method of MN in lab scale, MN-assisted TDDS＇s applications in small chemical drugs, macromolecular chemical drugs and bio-macromolecular drugs. We have also explored the bottlenecks for the future study and development prospect of MN-assisted TDDS. Key words：

关 键 词：微针 经皮给药系统 透皮吸收 微孔通道 综述 

分 类 号：R944.9[医药卫生—药剂学]