三甲基苯醌氢化过程的在线红外光谱控制  

In situ Monitoring of the Hydrogenation Process of 2,3,5-Trimethyl Benzoquinone by React Infrared Spectrum

作　　者：王康林 孙月婷[2] 皮士卿[3] 林子荣 

机构地区：[1]平光制药股份有限公司,安徽合肥231131 [2]安徽省地质实验研究所,安徽合肥230011 [3]浙江医药股份有限公司新昌制药厂,浙江新昌312500

出　　处：《中国医药工业杂志》2017年第7期1070-1074,共5页Chinese Journal of Pharmaceuticals

基　　金：安徽省第二批特支计划创新人才项目(2016030)

摘　　要：本研究利用在线红外光谱仪监测三甲基苯醌氢化反应过程并进行终点判断。选取原料三甲基苯醌和产物三甲基氢醌的特征红外光谱,分别建立三甲基氢醌在1 718 cm^(-1)、三甲基苯醌在1 652 cm^(-1)处吸光度值与浓度的标准曲线。在4种反应参数下,用建立的标准曲线模拟三甲基苯醌氢化过程中不同时刻反应液中产物和原料的浓度值,结果表明建立的标准曲线模型能较好地预测反应液中原料及产物浓度的变化,从而快速判断氢化反应终点。The variation of the absorption peaks of the characteristic functional groups in the hydrogenation reaction of trimethyl benzoquinone was investigated by react infrared spectrum. The 1 652 cm t wavelength of trimethyl benzoquinone and 1 718 cm 1 wavelength of trimethyl hydroquinone were selected as the characteristic infrared absorpition peaks, respectively. The standard curves were established with determination of the characteristic infrared absorption values from the different concentrations both of reactant and product. Under four reaction parameters, the concentrations of the products and reactants in the hydrogenation reaction system were simulated by the established standard curves. The results showed that the standard curve modeling could predict the concentration change of reactant and product in the hydrogenation reaction system, so as to quickly judge the endpoint of hydrogen reaction.

关 键 词：三甲基苯醌 在线红外光谱 氢化反应 终点判断 

分 类 号：R917[医药卫生—药物分析学]