microRNA-17-92家簇对骨发育、骨重塑和骨代谢的调控作用  

Regulation of micro RNA-17-92 cluster on bone development,remodeling,and metabolism

作　　者：万珊[1] 余希杰[1] 

机构地区：[1]四川大学华西医院内分泌科/内分泌与代谢病研究室,成都610041

出　　处：《中国修复重建外科杂志》2017年第7期870-875,共6页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金资助项目(81370969;81572639);高等学校博士学科点专项科研基金资助项目(20130181110066);成都市科学技术局基金项目(2014-HM01-00382-SF)~~

摘　　要：目的综述micro RNA-17-92家簇对骨发育、骨重塑和骨代谢的调控作用。方法查阅国内外相关文献,从临床遗传表型、动物实验及细胞研究3个不同层面进行阐述,探讨其可能的调控机制。结果 micro RNA-17-92家簇广泛参与生物体生理状态下的器官发育、病理状态下肿瘤的发生发展。近年研究表明,micro RNA-17-92家簇与其上游转录因子、下游靶蛋白组成错综复杂的分子信号网络精细调控骨骼生长发育、重塑和代谢。结论目前基础研究对micro RNA-17-92家簇调控骨骼系统的发育、重塑和代谢过程机制有一定了解,但确切机制尚未明确。Objective To review the regulation ofmicroRNA-17-92 cluster on bone development, remodeling, and metabolism. Methods The related literature was reviewed. The clinical genetic phenotype, animal experiment, and cell research were illustrated so as to explore the possible regulatory mechanisms. Results MicroRNA-17-92 cluster is involved in physiological normal organs development, pathological neoplasm occurrence, and development. Recently, studies have shown that microRNA-17-92 cluster constitutes an intricate molecular signaling network with its upstream transcription factors and downstream targeting proteins, which controls bone development, remodeling, and metabolism exquisitely. Conclusion Present fundamental researches have certain understanding of the regulatory mechanisms of microRNA-17-92 cluster on bone development, remodeling, and metabolism. However, the exact mechanisms under these processes remain unknown.

关 键 词：MicroRNA-17—92家簇 骨骼发育 骨重塑 骨代谢 Feingold综合征 

分 类 号：R580[医药卫生—内分泌] R681[医药卫生—内科学]