泻肺化瘀法对痰瘀阻肺型高原性肺动脉高压患者肺血管活性因子的影响  

Effect of Traditional Chinese Medicine Purging Lung and Removing Blood Stasis Method on Pulmonary Vascular Active Factors in Patients with Pulmonary Hypertension Induced by Phlegm and Blood Stasis

作　　者：星海霞[1] 姚惠青[1] 赵永祥[1] 吕华[1] 

机构地区：[1]青海省中医院呼吸科,青海西宁810003

出　　处：《中华中医药学刊》2017年第7期1870-1872,共3页Chinese Archives of Traditional Chinese Medicine

基　　金：青海省科技计划项目(2011-Z-726)

摘　　要：目的:观察泻肺化瘀法治疗痰瘀阻肺型高原性肺动脉高压患者的疗效及对肺血管活性因子的影响。方法:观察组60例,用前列地尔治疗14 d+泻肺化瘀类中药治疗28 d;对照组58例,单用前列地尔治疗14 d,停中药后观察两组患者疗效及肺血管活性因子指标治疗前后变化。结果:观察组总有效率90.0%高于对照组77.59%;观察组IMD、ADM、ET-1及m PAP下降更显著,观察组CRP、IL-6、TNF-a、5-HT及AT-II下降更显著。结论:泻肺化瘀类中药可提高体内PaO_2水平,并可降低IMD、ADM、ET-1、CRP、IL-6、TNF-a、5-HT及AT-II等因子在肺动脉高压患者的表达,具有较好的治疗效果。Objective： To observe the therapeutic effect of purging lung and removing blood stasis in the treatment of pulmonary hypertension in patients with phlegm and blood stasis type. Method： There were 60 cases in the observation group which used Alprostadil treatment for 14 days and purging lung and removing blood stasis treatment for 28 days. There were 58 cases in the control group which only used Alprostadil treatment for 14 days. The efficacy of the two groups and the pulmonary vascular active factors were observed after treatment. Result ： The total effective rate of the observation group was 90%. It was higher than the total effective rate of the control group. The total effective rate of the control group was 77.59%. The IMD, ADM, ET - 1 and mPAF of the observation group decreased significantly than those of the con- trol group. The observation group＇ s CRP, IL - 6, TNF - α, 5 - HT and AT - II decreased more significantly. Conclu- sion： Purging lung and removing blood stasis drugs can improve the level of PaO2 in vivo and can reduce the expressions of IMD, ADM, ET - 1, CRP, IL - 6, TNF - or, 5 - HT and AT - II and other factors in patients with puhnonary hyper- tension, which has good therapeutic effect.

关 键 词：高原性肺动脉高压 痰瘀阻肺型 泻肺化瘀法 肺血管活性因子 

分 类 号：R543.2[医药卫生—心血管疾病]