南鹤虱中愈创木烷型倍半萜类化学成分研究  

Guaiane-type sesquiterpenes from the fruits of Fructus carotae

作　　者：刘贵园 温楠[1] 张茂生[1] 徐应淑[1] 付少彬[1] 肖世基[1] 

机构地区：[1]遵义医学院药学院,贵州遵义563000

出　　处：《药学学报》2017年第7期1146-1149,共4页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(31560102);贵州省教育厅自然科学研究资助项目(黔教合KY字[2015]362);遵义医学院药物化学学科建设经费资助

摘　　要：为了阐明中药南鹤虱的化学成分,采用各种柱色谱及制备液相色谱进行分离纯化,从南鹤虱中分离得到9个愈创木烷型倍半萜成分,经理化性质和波谱数据确定其结构分别为11-羟基-8β-当归酰氧基-4-愈创木烯-3-酮(1)、11-乙酰氧基-4-愈创木烯-3-酮(2)、11-乙酰氧基-8β-异丁酰氧基-4-愈创木烯-3-酮(3)、11-乙酰氧基-8β-丙酰氧基-4-愈创木烯-3-酮(4)、11-羟基-4-愈创木烯-3-酮(5)、1β-羟基-11-乙酰氧基-8β-当归酰氧基-4-愈创木烯-3-酮(6)、11-乙酰氧基-8β-当归酰氧基-4-愈创木烯-3-酮(7)、8β-羟基-11-乙酰氧基-4-愈创木烯-3-酮(8)和8β,11-二羟基-4-愈创木烯-3-酮(9)。其中化合物1为新化合物,化合物5为新的天然产物,化合物2~4为首次从该属植物中分离得到的。To study the chemical constituents of the fruits of Fructus carotae, silica gel column chromatography and preparative HPLC were used to isolate and purify the extract of Fructus carotae. The structures of obtained compounds were elucidated on the basis of physicochemical property and spectral data. Nine guaiane-type sesquiterpenes were isolated and identified as 8β-angeloyloxy-11-hydroxy-4-guaien-3-one（1）, 11-acetoxy-4-guaien-3-one（2）, 11-acetoxy-8β-isobutyryl-4-guaien-3-one（3）, 11-acetoxy-8β-propionyl-4-guaien-3-one（4）, 11-hydroxy-4-guaien-3-one（5）, 11-acetoxy-8β-angeloyloxy-1β-hydroxy-4-guaien-3-one（6）, 11-acetoxy-8β-angeloyloxy-4-guaien-3-one（7）, 11-acetoxy-8β-hydroxy-4-guaien-3-one（8） and 8β,11-dihydroxy-4-guaien-3-one（9）. Compound 1 is a new compound, compound 5 is a new natural product, and compounds 2-4 were isolated from this genus for the first time.

关 键 词：南鹤虱 野胡萝卜 伞形科 愈创木烷 倍半萜 化学成分 

分 类 号：R284[医药卫生—中药学]