舒血宁注射液联合神经节苷脂对急性重度CO中毒患者的保护作用  

Protective effects of Shuxuening Injection combined with ganglioside on patients with acute severe carbon monoxide poisoning

作　　者：何佳起 齐洪娜[1] 孔繁托 安立娟[1] 肖青勉[1] 王维展[1] 刘倩[1] 

机构地区：[1]河北医科大学附属哈励逊国际和平医院急救医学部,河北衡水053000

出　　处：《中成药》2017年第7期1361-1365,共5页Chinese Traditional Patent Medicine

基　　金：河北省衡水市科学技术研究与发展计划项目(13019A)

摘　　要：目的考察舒血宁注射液(银杏叶提取物)联合神经节苷脂对急性重度一氧化碳中毒患者脑氧利用率和乳酸清除率的影响。方法 2011年3月至2016年3月入住河北医科大学附属哈励逊国际和平急救医学部的262例急性重度一氧化碳中毒患者随机分为对照组、舒血宁注射液组、神经节苷脂组和舒血宁注射液联合神经节苷脂治疗组(联合用药组)。所有患者检测颈动脉血和静脉血的氧饱和度,动脉血乳酸,治疗前及治疗后6 h、24 h、3 d脑氧利用率和乳酸清除率;观察2周后的临床症状、急性一氧化碳中毒后迟发性脑病的发生率及病死率。结果舒血宁注射液联合神经节苷脂治疗组总有效率高于其他组,联合用药组治疗后6、24 h脑氧利用率明显低于其他组,但乳酸清除率明显高于其他组;联合用药组患者迟发性脑病的发生率和病死率明显低于其他组。所有差异均有统计学意义。结论舒血宁和神经节苷脂联合用药治疗急性重度一氧化碳中毒患者的疗效好于分别用药。AIM To investigate the effects of Shuxuening Injection （Ginkgo biloba extract） combined with ganglioside on cerebral oxygen utilization coefficient （OzUCc） and lactate clearance rate （LCR） in patients with acute severe carbon monoxide poisoning （ASCOP）. METHODS Two hundred and sixty-two patients with AS- COP treated in emergency department of Harrison International Peace Hospital Affiliated to Hebei Medical Universi- ty from Mar 2011 to Mar 2016 were randomly divided into control group , Shuxuening Injection group, ganglioside group and Shuxuening Injection combined with ganglioside （combined medication） group. The changes were detec- ted in oxygen saturations of carotid blood and jugular blood, arterial blood lactic acid, O2UCc and LCR in all pa- tients before and 6, 24 hours, 3 days after the treatment. The clinical symptoms, and the mortality and morbidity of delayed encephalopathy after acute carbon monoxide poisoning after two weeks were observed. RESULTS Total effective rate of the combined medication group was higher than that of the other groups. O2 UCc at 6, 24 hours af- ter the treatment in the combined medication group were significantly lower than those in the other groups, so did the mortality and morbidity of delayed encephalopathy after acute carbon monoxide poisoning, but LCR was signifi- cantly higher than that in the other groups. All the differences had statistical significances. CONCLUSION The efficacy of combined medication of Shuxuening Injection and ganglioside in ASCOP patients is better than that of ap-plying single administration separately.

关 键 词：舒血宁注射液 神经节苷脂 联合用药 急性重度一氧化碳中毒 脑氧利用率 乳酸清除率 

分 类 号：R287[医药卫生—中药学]