骨质疏松与动脉钙化的相关性进展  

Progress in the Research on Relationship between Osteoporosis and Arterial Calcification

作　　者：刘建伟[1] 畅彦红[1] 徐扬[1] 仉珊珊 罗善顺[1] 

机构地区：[1]哈尔滨医科大学附属第一医院干部一病房,哈尔滨150001

出　　处：《医学综述》2017年第13期2506-2510,2515,共6页Medical Recapitulate

基　　金：国家自然科学基金(81270366)

摘　　要：骨质疏松与血管钙化是常见的老年性疾病,严重威胁老年人的生活健康,增加社会负担。大量循证医学证明骨质疏松与血管钙化相关联。动物实验结果显示,动脉硬化或者钙化过程复杂,类似正常的成骨过程。骨桥蛋白、骨形成发生蛋白家族、基质Gla蛋白、骨保护素等蛋白或基因既在成骨过程中发挥重要作用,又在动脉硬化或钙化过程中起作用。还有一些因素,如遗传、氧化应激、炎症也发挥重要作用。该文就两者之间的临床关系和发病机制进行初步探讨,为临床工作提供防治思路。Osteoporosis and vascular calcification is a common age-related diseases, a serious threat to the life and health of the elderly, an increase to the burden on society. A large number of evidence-based medicine studies suggest that osteoporosis is associated with vascular calcification. Animal experimental results show that the hardening of the arteries or calcification process is complex, similar to the normal process of osteogenesis. Osteopontin, bone morphogenetic protein family, Gla protein matrix, bone protection element, such as proteins or genes play important roles in the process of osteogen- esis,and play roles in hardening or calcification of the arteries. There are some other factors, such as genetic, oxidative stress, inflammation, which also play important roles. Here is to explore the clinical relationship between them and the patho- genesis, providing ideas for the prevention and control in the clinical practice.

关 键 词：骨质疏松 血管钙化 炎症 

分 类 号：R592[医药卫生—老年医学]