血浆氧化还原电位在造血干细胞移植术后移植物抗宿主病监测中的临床应用  

Clinical application of the redox potential of blood plasma in monitoring GVHD after HSCT

作　　者：钟凌[1] 陈姣[2] 黄晓兵[2] 李焱鑫[1] ZHONG Ling CHEN Jiao HUANG Xiao-bing LI Yan-xin(Clinical Laboratory Department of Hema- tology ,Sichuan Academy of Medical Sciences ＆ Sichuan Provincial People＇s Hospital, Chengdu 610072, China)

机构地区：[1]四川省医学科学院.四川省人民医院检验科,四川成都610072 [2]四川省医学科学院.四川省人民医院血液科,四川成都610072

出　　处：《实用医院临床杂志》2017年第4期33-36,共4页Practical Journal of Clinical Medicine

摘　　要：目的探讨血浆氧化还原电位在监测移植物抗宿主病(graft versus-host disease,GVHD)中的临床应用。方法随访2009年1月至2015年12月进行造血干细胞移植的患者59例,移植术后定期随访同时取空腹静脉血,测定血浆氧化还原电位。正常对照组由59例健康体检者组成。结果正常对照组血浆RP值为-56.2^-11.2 m V。42例未发生GVHD患者血浆RP值为-20.8~21.1 m V,RP值波动幅度△m V为4.4~11.3 m V。17例发生GVHD患者血浆RP值为10.6~38.8 m V,△m V为25.8~61 m V。急性GVHD I级患者血浆RP值为9.8~27.3 m V,II级为3.7~35.1 m V,III级为19.6~43.9 m V,IV级为25.4~49.5 m V。结论血浆RP值的变化与GVHD可能具有一定的关联,且无创、简便,适宜于临床推广。Objective To investigate the clinical application of Redox potential of blood plasma in monitoring graft-versus-host disease （GVHD） after hematopoietic stem cell transplantation （HSCT）. Methods We followed up 59 patients accepted HSCT from Jan 2009 to Dec 2015. During the regular follow-up after HSCT,fasting venous blood samples were taken and redox potential （RP） in blood was measured, At the same time ,59 healthy subjects were used as normal control. Results The plasma RP values were-56. 2 ~ - 11.2 mV in normal control group. The plasma RP values were-20. 8 ~ 21.1 mV in 42 patients who did not have GVHD during the period of follow-up. The fluctuation range （ △mV） were in 4. 4 ~ 11.3 mV. The plasma RP values were 10. 6 ~38. 8 mV and A mV were 25.8 ~61 mV in 17 patients who had GVHD. The RP values were 9.8 ~27.3 mV,13.7 ~35.1 mV,19.6 ~43.9 mV and 25.4~49.5 mV in patients with I to IV degree of acute GVHD,respectively. Conclusion The changes of blood plasma PR values may be associated with GVHD. The measurement of PR value is invasive and simple that is suitable for promotion.

关 键 词：氧化还原电位 血浆 造血干细胞移植 移植物抗宿主病 

分 类 号：R446.62[医药卫生—诊断学]