维生素AD波浪式剂量给药方法对预防婴儿维生素D缺乏病的效果分析  

Analysis of the Effect of Vitamin D Wave-type Dosing Method on Prevention of Vitamin D Deficiency in Infants

作　　者：杨建荣[1] 张健[1] 王丽丽[1] 孟宪萍[1] 胡凤娥[1] 

机构地区：[1]河北省玉田县医院儿二科,玉田064100

出　　处：《中国医药导刊》2017年第5期497-498,共2页Chinese Journal of Medicinal Guide

基　　金：河北省2016年度医学科学研究重点课题(项目编号:20160889);项目名称:维生素AD改善反复呼吸道感染患儿免疫功能及时效关系

摘　　要：目的:采取维生素AD波浪式剂量给药方式用药并观察此种给药方式对婴儿维生素D缺乏病症的预防效果。方法:选取我院2013年6月~2015年10月在社区建档的符合纳入标准的婴儿共400例作为此次研究的对象,将这些婴儿随机平均分为两组,称为试验组与对照组,每组婴儿各200例。其中,试验组婴儿的给药方式为波浪式剂量给药方式,对照组婴儿的给药方式为传统给药方式。在婴儿出生后的4~6周对婴儿进行第一次随访,此后婴儿出生起3个月、6个月、9个月以及12个月都对婴儿进行一次随访,共计五次。观察记录每次随访中婴儿贫血、维生素D缺乏状况、骨骼指征、婴儿1年平均下来的得病次数以及婴儿是否存在不良反应等等指标,并进行比较。结果:经1年时间观察后,两组间除贫血与骨骼指征方面差异无统计学意义(P>0.05)外,其余各项间差异均具有统计学意义(P<0.05),实验组家长对于给药方式的经济性与便捷性评分明显高于对照组,组间差异具有统计学意义(P<0.05)。结论:在安全剂量下实行波浪式剂量给药方式对婴儿进行维生素AD给药可行,此种方式可有效提高药效、具有一定经济性并且操作简便。Objective：Take vitamin AD wave dosage administration method and observe the effect of this way of administration on the prevention of vitamin D deficiency in infants.Methods：A total of 400 infants who met the inclusion criteria in our hospital from June 2013 to October 2015 were selected as the subjects of the study.The infants were randomly divided into two groups,Group and control group,each group of 200 infants.Infants in the experimental group were administered in the form of wavy dose,while those in the control group were in the traditional mode of administration.Infants were first followed up at 4 ～ 6 weeks of age,and infants were followed up for 3,6,9,and 12 months,five times in total.Vitamin D deficiency status,skeletal indications,the average number of sick infants in a year,and the presence of adverse reactions in infants were recorded and compared during each follow-up.Results：There was no significant difference between the two groups （P 〉 0.05） except for anemia and skeletal indications after one year of observation （P 〉 0.05）.The differences among the other items were statistically significant （P 〈 0.05） The economic and convenience frequency of drug administration was significantly higher than that of the control group,and there was significant difference between the two groups （P 〈 0.05）.Conclusion：In a safe dose under the implementation of wave-dose administration of vitamin AD in infants may be feasible,this approach can effectively improve the efficacy,with a certain econony and easy to operate.

关 键 词：维生素AD 波浪式剂量给药 婴儿维生素D缺乏 预防 

分 类 号：R723.2[医药卫生—儿科] R591.4[医药卫生—临床医学]