盾叶薯蓣中甾体皂苷的分离与结构鉴定  

Isolation and structure identification of steroid saponins from Dioseorea zingiberensis C.H.Wright

作　　者：金明[1] 仙靓 孙丽娜[1] 石硕[1] 张卉[1] 张新新[1] 郭增军[1] 

机构地区：[1]西安交通大学药学院,西安710061

出　　处：《西北药学杂志》2017年第4期395-399,共5页Northwest Pharmaceutical Journal

基　　金：国家自然科学基金项目(编号:81603267);中国博士后科学基金面上项目(编号:2016M590958);陕西省卫生科研基金(编号:2016D089);西安交通大学新讲师科研启动基金(编号:1191320023)

摘　　要：目的对盾叶薯蓣根茎中甾体皂苷类的化学成分进行研究。方法利用常规柱层析法与制备型HPLC法相结合对盾叶薯蓣中的活性成分进行分离纯化,通过1 H-NMR、13 C-NMR和MS等光谱法鉴定单体化合物的结构。结果从盾叶薯蓣根茎中共分离得到了20个甾体皂苷化合物,其中7个化合物为首次从该植物中发现。结论盾叶薯蓣根茎中主要含有螺甾烷型和呋甾烷型甾体皂苷。Objective To study the chemical constituents of steroid saponins fromDioseorea zingiberensis C.H.Wright（D.zingiberensis）.Methods The bioactive ingredients of D.zingiberensis were isolated and purified using normal column chromatography combined with preparative HPLC.The structures of single compounds were identified by ^1H-NMR,^13C-NMR and MS.Results 20 compounds were finally obtained from the rhizomes of D.zingiberensis among which 7were firstly isolated from this plant.Conclusion Steroid saponins in the rhizome of D.zingiberensis were mainly composed of spirostanol and furostanol saponins.

关 键 词：盾叶薯蓣 甾体皂苷 分离纯化 结构鉴定 

分 类 号：R284[医药卫生—中药学]