顶空气相色谱法测定氟[^(18)F]脱氧葡糖注射液中有机溶剂残留量  

Determination of residual organic solvents in Fludeoxyglucose [^(18)F]Injections by headspace gas chromatography

作　　者：王庆芬[1] 杨丽娜[1] 倪晓霞[1] 林跃松 刘威宏[1] 

机构地区：[1]解放军第一七五医院/厦门大学附属东南医院,漳州363000

出　　处：《西北药学杂志》2017年第4期465-467,共3页Northwest Pharmaceutical Journal

摘　　要：目的建立顶空气相色谱法测定氟[^(18)F]脱氧葡糖注射液中3种有机溶剂残留量的方法。方法采用顶空毛细管气相色谱法,Thermo TG-WAXMS毛细管柱(30m×0.25mm,0.5μm),以氮气为载气,采用氢火焰检测器(FID)为检测器,程序升温:初始50℃,维持8min,以30℃·min-1升温至130℃,保持2min。结果乙醇、丙酮和乙腈3种有机溶剂均达到完全分离,在考察的质量浓度范围内线性关系均良好,高、中、低3种质量浓度的回收率为97.6%~99.0%。结论该方法灵敏度、准确度均达到有机溶剂残留量的检测要求,可用于氟[^(18)F]脱氧葡糖注射液中3种有机溶剂残留量的检测和分析。Objective To establish a headspace gas chromatography method for the determination of residual organic solvents（ethanol,acetone and acetonitrile）in Fludeoxyglucose[18 F]Injections.Methods Headspace gas chromatography was adopted using a Thermo TG-WAXMS capillary column（30m×0.25 mm,0.5μm）with nitrogen as the carrier gas and flame ionization detector（FID）as the detector.The initial column temperature was set at 50 ℃,maintained for 8min,and then raised（30 ℃·min^-1）to130 ℃,and maintained for another 2 min.Results The 3residual organic solvents（ethanol,acetone and acetonitrile）were completely separated.A good linearity in the experimental concentration was observed.The average recoveries were between 97.6%-99.0%.Conclusion The method is sensitive and accurate,and can be used for the determination of 3residual organic solvents in Fludeoxyglucose[-（18）F]Injections.

关 键 词：氟[^18F]脱氧葡糖注射液 有机溶剂残留 顶空气相色谱法 

分 类 号：R927.2[医药卫生—药学]