黄芪四君子汤对妊娠期糖尿病的疗效分析  

Effect of Huangqi Sijunzi decoction on gestational diabetes mellitus

作　　者：吴剑[1] 于四永[1] 王艳会[1] 王颖 向蕊 

机构地区：[1]唐山市妇幼保健院内科,河北唐山063000 [2]华北理工大学附属医院内科,河北唐山063000

出　　处：《国际检验医学杂志》2017年第13期1759-1761,1764,共4页International Journal of Laboratory Medicine

摘　　要：目的分析黄芪四君子汤治疗妊娠糖尿病(GDM)的疗效及对Mg^(2+)、CRP、脂联素水平、并发症发生的影响。方法将唐山市妇幼保健院2015年8月至2017年1月接诊的130例GDM患者纳入研究,随机将患者分为观察组和对照组各65例,给予对照组患者常规治疗,观察组患者在常规治疗的基础上加用黄芪四君子汤治疗,观察两组患者治疗前后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)及血清Mg^(2+)、CRP和脂联素水平以及治疗后并发症发生情况。结果治疗后,观察组的FPG[(5.30±0.3)mmol/L]、2hPG[(5.36±0.27)mmol/L]、HbA1c[(5.58±1.29%)]水平均低于对照组FPG[(5.68±0.38)mmol/L]、2hPG[(6.01±0.33)mmol/L]、HbA1c[(6.86±1.35)%],两组间比较差异有统计学意义(P<0.05);观察组的Mg^(2+)水平[(1.25±0.36)mmol/L]和脂联素水平[(35.24±5.18)μg/L]高于对照组Mg^(2+)水平[(0.91±0.30)mmol/L]和脂联素水平[(30.76±4.85)μg/L],CRP水平[(1.59±0.35)mg/L]低于对照组[(2.21±0.46)mg/L],两组比较差异均有统计学意义(P<0.05);观察组患者出现腹痛、腹胀、低血糖的不良反应发生率(9.23%)低于对照组(38.46%),两组比较差异有统计学意义(P<0.05);观察组患者治疗后的临床疗效总有效率(96.92%)高于对照组(87.69%),两组比较差异有统计学意义(P<0.05)。结论黄芪四君子汤在GDM治疗中能有效降低血糖,改善Mg^(2+)、CRP、脂联素等相关指标,降低并发症发生率,效果显著,值得临床上的广泛应用。Objective To investigate the effect of Huangqi four Decoction in treating gestational diabetes mellitus(GDM)and its effect on the levels of Mg^(2+),CRP,adiponectin and complications.Methods In our hospital from August 2015 to January 2017 were 130cases of gestational diabetes patients as the research object,the patients were randomly divided into observation group and control group with 65 cases in each group,the control group was given conventional treatment,patients in the observation group in the conventional treatment based on the use of Astragalus four gentleman decoction,observe two groups of patients before and after fasting blood glucose(FPG),2hpostprandial blood glucose(2hPG),glycosylated hemoglobin(HbA1c),and Mg^(2+),CRP and serum adiponectin levels and occurrence of complications after treatment and the curative effect.Results After treatment,the observation group FPG[(5.30±0.3)mmol/L],2hPG[(5.36±0.27)mmol/L],HbA1c[(5.58±1.29%)]levels were lower than those of control group[(5.68±0.38)mmol/L,(6.01±0.33)mmol/L,(6.86±1.35)%],the two groups was statistically significant(P<0.05).In the observation group,Mg^(2+)[(1.25±0.36)mmol/L]and adiponectin[(35.24±5.18)μg/L]levels were higher than those of the control group[(0.91±0.30)mmol/L and(30.76±4.85)μg/L],while CRP [(1.59±0.35)mg/L]was lower than control group[(2.21±0.46)mg/L],the difference was statistically significance(P<0.05);observation group of adverse reactions in patients with abdominal pain,abdominal distension,the incidence of hypoglycemia(9.23%)than in the control group(38.46%),the two groups was statistically significant(P<0.05);the patients in observation group after treatment The total effective rate(96.92%)was higher than that of the control group(n=87.69%),and the difference between the two groups was statistically significant(P<0.05).Conclusion Astragalus four Decoction in the treatment of gestational diabetes can effectively reduce blood glucose,improve Mg^(2+),CRP,adiponectin and other related indicators,reduce the incidence of co

关 键 词：黄芪四君子汤 妊娠糖尿病 血糖 疗效 

分 类 号：R714.256[医药卫生—妇产科学]