复方敏维糖浆对小儿急性湿疹荨麻疹患者血清IL-4、IFN-γ水平的影响研究  

Effect of compound Minwei syrup on serum IL-4 and IFN-γ in children with acute urticaria and eczema

作　　者：贾慧军[1] 王建茹[2] 陈海赑 唐靖禹[1] 杨奇[1] 王国辉[1] 

机构地区：[1]唐山市妇幼保健院药剂科,河北唐山063000 [2]唐山市妇幼保健院检验科,河北唐山063000

出　　处：《国际检验医学杂志》2017年第13期1765-1766,1769,共3页International Journal of Laboratory Medicine

基　　金：唐山市科学技术研究与发展指导项目(121302113a)

摘　　要：目的分析小儿急性湿疹荨麻疹应用复方敏维糖浆治疗时对患儿血清白细胞介素-4(IL-4)、干扰素-γ(IFN-γ)水平的影响。方法选择该院2015年3月至2016年10月接收的急性湿疹荨麻疹患儿148例,随机分为研究组和对照组,各74例,研究组患儿应用复方敏维糖浆治疗,对照组患儿应用丹皮酚软膏治疗,观察治疗效果,分别于治疗前后评价患儿症状积分,并检测血清IL-4、IFN-γ水平。结果治疗前,两组患儿症状积分、血清IL-4、IFN-γ水平差异无统计学意义(P>0.05);治疗后,研究组临床疗效、血清IFN-γ水平高于对照组,症状积分、血清IL-4水平低于对照组,差异具有统计学意义(P<0.05)。结论急性湿疹荨麻疹患儿应用复方敏维糖浆治疗时,可明显缓解患儿症状,提高患儿机体免疫力,促进患儿康复,具有良好的治疗效果。Objective To analyze the effect of compound Minwei on serum interleukin-4(IL-4),interferon-γ(IFN-γ)value in children with acute urticaria.Methods in our hospital from March 2015 to October 2016 received 148cases of children with acute urticaria eczema,were randomly divided into study group and control group,74 cases in each group,study the application of compound chlorphenamine maleate and vitamin syrup for treatment,the control group were applied paeonol ointment treatment,curative effect,evaluation of children with symptoms before and after treatment respectively,and detection serum IL-4and IFN-levels.Results before treatment,the two groups had no statistical significance with symptom score,serum IL-4,IFN-levels difference(P>0.05);after treatment,the clinical efficacy of the study group,serum IFN-γlevels higher than the control group,the serum level of IL-4score,symptoms than the control group,the difference has statistical significance(P<0.05).Conclusion acute eczema urticaria children with compound Minwei syrup treatment,can significantly relieve the symptoms of children,improve the body immunity,promote children rehabilitation,has good treatment effect.

关 键 词：复方敏维糖浆 急性湿疹荨麻疹 白细胞介素-4 干扰素-Γ 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]