铅中毒和驱铅药物的研究进展  

Research progress on lead poisoning and development of deleading reagents

作　　者：何剪太[1] 朱轩仪[2] 巫放明 肖平[3] 

机构地区：[1]中南大学湘雅医院普外科,湖南长沙410008 [2]中南大学湘雅医院国家卫生和计划生育委员会纳米生物技术重点实验室,湖南长沙410008 [3]中南大学湘雅医院肾内科,湖南长沙410008

出　　处：《中国现代医学杂志》2017年第14期53-57,共5页China Journal of Modern Medicine

基　　金：国际合作项目(No:2013DFA31440)

摘　　要：铅中毒是一种铅暴露引起的直接损害神经系统并累及多种器官的疾病。由于铅在日常生活中应用广泛,铅中毒已经成为一种常见疾病。本研究就铅中毒及其对神经、造血、骨骼、生殖系统及肾脏损伤做综述,并描述应用于驱铅药物研究的细胞和动物模型以及阐述常用驱铅药物的利弊,重点介绍了通过阻断肝肠循环治疗铅中毒的研究。Lead poisoning is a disease caused by lead exposure which can direct ly damage the nervous system and other organs. Since lead is widely used in dai lyli fe, lead poisoning has become a common disease. This paper reviews lead poisoning and its damages in the nerve system, hematopoiet ic system, skeletal system, reproduct ive system and kidneys, also descr ibes some cell and animal models of lead poisoning for deleading drug research, and explains the advantages and disadvantages of the commonly-used deleading drugs. Important ly, this review int roduces a new concept of therapeut ics of lead poisoning by blocking the enterohepat ic circulat ion.

关 键 词：铅中毒 驱铅药物 肝胆循环 细胞模型 动物模型 

分 类 号：R595[医药卫生—内科学]