白细胞介素-22对成人左半肝切除术后残肝功能及再生恢复的影响  

The impact of interleukin-22 on early remnant liver function restoration after left lobe resection

作　　者：崔子林[1] 刘子荣[1] 刘晓龙[1] 王建[1] 史瑞[1] 王连江[1] 李阳[1] 吴迪[1] 田青[1] 张雅敏[1] 

机构地区：[1]天津市第一中心医院器官移植中心肝胆外科,300192

出　　处：《中华实验外科杂志》2017年第7期1105-1107,共3页Chinese Journal of Experimental Surgery

基　　金：国家自然科学基金面上项目（81370576）;天津市卫生局科技基金重点项目（2013KR05）

摘　　要：目的探讨白细胞介素-22（IL-22）对成人左半肝切除术后残肝功能和再生的情况、恢复的作用及肝再生情况的相关性，以及相关不同临床因素对IL-22表达的影响。方法60例左半肝切除患者纳入本研究，利用逐步回归分析比较术后不同时间点IL-22与丙氨酸转氨酶（ALT）、天冬氨酸转氨酶（AST）、肝脏再生率（LRR）及临床因素的相关关系。结果术前、术后3、7、14 d的ALT[（98±10）、（360±39）、（135±21）、101±19） U/L]、AST[（179±35）、（435±188）、（251±22）、（171±25） U/L]水平与IL-22（0.145±0.049、0.193±0.050、0.177±0.083、0.149±0.073）的表达水平呈正相关（R=0.712、0.854，P=0.037、0.022）；术后3、7、14 d残肝LRR[（13±6）%、（29±12）%、（38±17）%]的差异有统计学意义（P=0.009），以术后7 d以内增长幅度最大，之后为缓慢增长；残肝是否保留肝中静脉IL-22表达的差异无统计学意义（P=0.555、0.528、0.378）。结论肝切除术后IL-22大量表达，促进残肝功能的修复及对肝脏的再生可能具有一定的相关性，而术式对IL-22表达的影响甚小。Objective To evaluate the impact of interleukin-22 （IL-22） on early remnant liver function and the relation on the regeneration after left lobe resection as well as the relation of IL-22 and influencing factors.Methods 60 cases from Tianjin Conclusion The expression of IL-22 increased after left lobe resection, which promoted the first central hospital with left lobe resection were included in this study, alanine aminotransferase （ALT）, aspartate aminotransferase （AST）, liver regenerative ratio （LRR） and clinic factors are compared with the expression of IL-22 after left lobe resection, and stepwise regression analysis was done to set up the regression equation.Results There were positive correlation between the ALT （98±10, 360±39, 135±21, 101±19） U/L, AST （179±35, 435±188, 251±22, 171±25） U/L and IL-22 （0.145±0.049, 0.193±0.050, 0.177±0.083, 0.149±0.073） at the time of preoperation and postoperative 3, 7, 14 days （R=0.712, P=0.037, R=0.854, P=0.022）; The difference between LRRs [（13±6）%, （29±12）%, （38±17）%] at different stages after left lobe resection were significant （P=0.009）. The growth within 7 days were the largest, and then slowly; The inclusionof middle hepatic vein had no significantinfluence on IL-22 after left lobe resection （P=0.555, 0.528, 0.378）.Conclusion The expression of IL-22 increased after left lobe resection, which promoted the restoration restoration of liver function and maybe had the relation on the liver regeneration, however, surgical methods had little influence on the expression of IL-22.

关 键 词：白细胞介素-22 左半肝切除 肝再生 肝功能 

分 类 号：R657.3[医药卫生—外科学]