WRAP53β的分子功能及其在疾病中的作用  

Molecular Function of WRAP53β and Its Role in Diseases

作　　者：陈洁莹[1] 孙洋[1] 杨潮[2] 李江林[1] 叶茂[1] CHEN Jie-ying SUN Yang YANG Chao LI Jiang-lin YE Mao(College of Bialogy, Hunan University, Changsha 410082, Hunan, China College of Life and Environment Science, Gannan Normal University, Ganzhou 341000, Jiangxi, China)

机构地区：[1]湖南大学生物学院,中国湖南长沙410082 [2]赣南师范大学生命与环境科学学院,中国江西赣州341000

出　　处：《生命科学研究》2017年第3期257-261,共5页Life Science Research

基　　金：国家重点基础研究发展计划"973项目"(2013CB932702);国家自然科学基金资助项目(81272220;81402304;81672760);湖南省自然科学基金资助项目(2016JJ3048)

摘　　要：WRAP53β蛋白是WD40重复蛋白家族的重要成员,能控制端粒酶、DNA修复蛋白和剪接因子在细胞内转运,参与卡哈尔体形成、端粒稳定和端粒延伸。目前研究表明WRAP53β功能异常与早衰、肿瘤、神经退行性疾病等密切相关,可能成为疾病治疗的一个新靶点。现就WRAP53β在细胞内多方面的分子功能及其与疾病关系的研究进展进行综述。The WRAP53β protein, an important member of the WD40 protein family, controls intracellular trafficking of telomerase, DNA repair proteins and the splicing factors, and is also involved in the formation of Cajal body, telomere stability and elongation. Dysfunction of this protein has been associated with prema- ture aging, cancer and neurodegeneration, and this suggests that WRAP53β will be a potential molecular tar- get in treatment of diseases. Here, the muhifaceted molecular functions of WRAP53β and its research progress in diseases were reviewed.

关 键 词：WRAP53β 卡哈尔体 DNA双链断裂 端粒酶 肿瘤 

分 类 号：Q71[生物学—分子生物学]