成纤维细胞生长因子的研究进展及口腔应用前景  

Research progress of fibroblast growth factors and application prospects in oral medicine

作　　者：王慧慧[1] 赵玉梅[1] WANG Huihui ZHAO Yumei.(Department of Pediatric Dentistry, Hospital of Stomatology, Tonal University, Shanghai Engineering Re- search Center of Tooth Restoration and Regeneration, Shanghai 200072, Chin)

机构地区：[1]同济大学附属口腔医院儿童口腔科上海牙组织修复与再生工程技术研究中心,上海200072

出　　处：《口腔医学》2017年第7期651-655,共5页Stomatology

基　　金：上海市科学技术委员会科研计划项目(14411963600)

摘　　要：成纤维细胞生长因子(fibroblast growth factors,FGFs)在多种生理和发育过程中发挥着至关重要的作用,它与细胞的生长,增殖,分化,迁移紧密相关。人类和啮齿类动物的成纤维细胞生长因子基因家族中包括22个成员(FGF1~FGF23,其中人类FGF15和鼠FGF19尚未明确),国内外的研究表明成纤维细胞生长因子参与胚胎发育、器官形成、组织修复、新陈代谢、肿瘤形成等多种过程中。但在多种成纤维细胞因子中,关于FGF11的报道相对较少。该综述详细介绍了FGFs的作用机制、生物学功能及研究进展,概括了FGF11的作用,并展望了FGFs在口腔医学研究方面的应用前景。Fibroblast growth factors （FGFs） are closely related with cell growth, proliferation, differentiation and migration, which play a key role in muhiple developmental and physiological processes. The mammalian FGF gene family consists of 22 members （FGF1- 23） , while human FGF15 and rats FGF19 haven＇ t been identified. Most studies have shown that FGFs were involved in the progress of embryonic development, organ formation, tissue repair, metabolism and tumor formation, however, the research on FGF11 is rarely reported. This review aims to summarize the mechanism, biological functions and research progress of FGFs, describe the function of FGFll, and provide an outlook of the application prospects of stomatological research on FGF.

关 键 词：牙齿发育 FGFs研究进展 FGF11 

分 类 号：R780.2[医药卫生—口腔医学]