阿奇霉素与阿莫西林-克拉维酸对儿童患者急性中耳炎抗感染治疗的疗效比较  

Comparison of Anti-infection Clinical Efficacies of Azithromycin and Amoxicillin-clavulanate in in Children Patients with Acute Otitis Medias

作　　者：肖南昌 卢晓华 许慕岚 

机构地区：[1]赣州市第五人民医院,江西赣州341000

出　　处：《抗感染药学》2017年第3期600-602,共3页Anti-infection Pharmacy

摘　　要：目的:比较阿奇霉素与阿莫西林-克拉维酸钾对患儿急性中耳炎抗感染治疗的临床疗效。方法:选取2015年8月—2016年9月间收治的急性中耳炎患儿90例,将其随机分为对照组(给予阿莫西林-克拉维酸钾治疗)和治疗组(给予阿奇霉素治疗),每组45例;比较治疗后两组患儿的阳性症状改善情况、不良反应发生情况以及住院时间。结果:治疗后两组患儿阳性症状的改善率与治疗前均有所改善(P<0.05),但两组治疗后之间的比较其差异无统计学意义(P>0.05);不良反应的发生率治疗组低于对照组,住院时间也短于对照组(P<0.05)。结论:急性中耳炎对患儿有较大的影响,采用阿奇霉素与阿莫西林-克拉维酸钾治疗的疗效相似,但阿奇霉素治疗后不良反应发生较少,安全性好,有效缩短了患者的住院时间。Objective： To compare the anti-infection clinical efficacies of azithromycin and amoxicillin-clavulanate in in children patients with acute otitis medias. Methods： 90 cases of acute otitis media in children as the research object, randomly divided into control group （treated with amoxicillin and potassium clavulanate） and experimental group （treated with azithromycin）, 45 cases were in each group; analysis of improvement and positive symptoms in the two groups after the treatment of adverse events and hospitalization time was conducted. Results： after treatment, two groups of children with positive symptoms were improved （P〈0.05）, but there was no significant difference between the two groups （P〉0.05） and in the occurrence of adverse reactions, the experimental group was with the low incidence rate and hospitalization time is shorter than the control group. The data were compared between the two groups which had significant difference（P〈0.05）. Conclusion： acute otitis media has a great influence on children. The clinical efficacy of azithromycin and amoxicillin-potassium clavulanate were basically similar, but less adverse reaction occurred af- ter azithronlycin treatment with good security, effectively shortened the hospitalization time of patients.

关 键 词：阿奇霉素 阿莫西林 克拉维酸钾 急性中耳炎 临床疗效 

分 类 号：R969.3[医药卫生—药理学]