海南狗牙花枝叶中1个新的8-O-4′-木脂素  

A new 8-O-4′-neolignan from twigs and leaves of Ervatamia hainanensis

作　　者：唐本钦[1] 陆建林[1] 孙建博[2] 

机构地区：[1]顺德职业技术学院,广东顺德528333 [2]中国药科大学,江苏南京210000

出　　处：《中草药》2017年第12期2371-2374,共4页Chinese Traditional and Herbal Drugs

基　　金：广东省自然科学基金项目(2016A030310017);广东省高等职业教育品牌专业建设项目(16061)

摘　　要：目的研究海南狗牙花Ervatamia hainanensis枝叶的化学成分。方法采用硅胶、ODS、Sephadex LH-20及制备型HPLC等柱色谱方法进行分离纯化,根据理化性质及波谱学数据鉴定化合物结构。结果从海南狗牙花枝叶的95%乙醇提取物中分离得到了4个木脂素类成分,分别鉴定为threo-7-O-ethylguaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(1)、threoguaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(2)、erythro-guaiacylglycerol-8-O-4′-(coniferyl alcohol)ether(3)、去氢二松柏醇(4)。结论化合物1为1个新的8-O-4′-木脂素类成分,命名为海南狗牙花脂素A(1);化合物2~4为首次从狗牙花属植物中分离得到。Objective To study the chemical constituents in the twigs and leaves of Ervatamia hainanensis. Methods The chemical constituents were isolated by silica gel, ODS, Sephadex LH-20 column chromatographies, and preparative HPLC. The structures were elucidated on the basis of physicochemical properties and spectral analysis. Results Four lignans were isolated and identified as threo-7-O-ethylguaiacylglycerol-8-O-4′-（coniferyl alcohol） ether（1）, threo-guaiacylglycerol-8-O-4′-（coniferyl alcohol） ether（2）, erythro-guaiacylglycerol-8-O-4′-（coniferyl alcohol） ether（3）, and dehydrodiconiferyl alcohol（4）. Conclusion Compound 1 is a new 8-O-4′-neolignan and named as hainanervaligan A（1）, and compounds 2—4 are obtained from the plants of Ervatamia（A. DC.） Stapf for the first time.

关 键 词：海南狗牙花 狗牙花属 木脂素 8-O-4′-木脂素 海南狗牙花脂素A 去氢二松柏醇 

分 类 号：R284.1[医药卫生—中药学]