Association between smoking and the risk of acute mountain sickness： a meta-analysis of observational studies  

作　　者：Chen Xu Hong-Xiang Lu Yu-Xiao Wang Yu Chen Sheng-hong Yang Yong-Jun Luo 

机构地区：[1]Department of Military Medical Geography, Third Military Medical University, Chongqing 400038, China [2]Battalion 5 of Cadet Brigade, Third Military Medical University, Chongqing 400038, China [3]Key Laboratory of High Altitude Environmental Medicine (Ministry of Education), Third Military Medical University, Chongqing 400038, China [4]Mountain Sickness Research Institute, 18th Hospital of PLA, Yecheng, Xinjiang 844900, China

出　　处：《Military Medical Research》2017年第1期14-19,共6页军事医学研究（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.81372125)

摘　　要：Background: People rapidly ascending to high altitudes(>2500m) may suffer from acute mountain sickness(AMS). The association between smoking and AMS risk remains unclear. Therefore, we performed a meta-analysis to evaluate the association between smoking and AMS risk.Methods: The association between smoking and AMS risk was determined according to predefined criteria established by our team. Meta-analysis was conducted according to the PRISMA guidelines. We included all relevant studies listed in the Pub Med and Embase databases as of September 2015 in this meta-analysis and performed systemic searches using the terms "smoking", "acute mountain sickness" and "risk factor". The included studies were required to provide clear explanations regarding their definitions of smoking, the final altitudes reached by their participants and the diagnostic criteria used to diagnose AMS. Odds ratios(ORs) were used to evaluate the association between smoking and AMS risk across the studies, and the Q statistic was used to test OR heterogeneity, which was considered significant when P<0.05. We also computed 95% confidence intervals(CIs). Data extracted from the articles were analyzed with Review Manager 5.3(Cochrane Collaboration, Oxford, UK).Results: We used seven case-control studies including 694 smoking patients and 1986 non-smoking controls to analyze the association between smoking and AMS risk. We observed a significant association between AMS and smoking(OR=0.71, 95% CI 0.52–0.96, P=0.03).Conclusion: We determined that smoking may protect against AMS development. However, we do not advise smoking to prevent AMS. More studies are necessary to confirm the role of smoking in AMS risk.Background： People rapidly ascending to high altitudes （〉2500m） may suffer from acute mountain sickness （AMS）. The association between smoking and AMS risk remains unclear. Therefore, we performed a meta-analysis to evaluate the association between smoking and AMS risk. Methods： The association between smoking and AMS risk was determined according to predefined criteria established by our team. Meta-analysis was conducted according to the PRISMA guidelines. We included all relevant studies listed in the PubMed and Embase databases as of September 2015 in this meta-analysis and performed systemic searches using the terms ＂smoking＂, ＂acute mountain sickness＂ and ＂risk factor＂. The included studies were required to provide clear explanations regarding their definitions of smoking, the final altitudes reached by their participants and the diagnostic criteria used to diagnose AMS. Odds ratios （ORs） were used to evaluate the association between smoking and AMS risk across the studies, and the Q statistic was used to test OR heterogeneity, which was considered significant when P〈0.05. We also computed 95% confidence intervals （CIs）. Data extracted from the articles were analyzed with Review Manager 5.3 （Cochrane Collaboration, Oxford, UK）. Results： We used seven case-control studies including 694 smoking patients and 1986 non-smoking controls to analyze the association between smoking and AMS risk. We observed a significant association between AMS and smoking （0R=0.71, 95% CI 0.52-0.96, P=0.03）. Conclusion： We determined that smoking may protect against AMS development. However, we do not advise smoking to prevent AMS. More studies are necessary to confirm the role of smoking in AMS risk.

关 键 词：SMOKING Acute mountain sickness ASSOCIATION High altitude META-ANALYSIS Risk factor 

分 类 号：R594.3[医药卫生—内科学]