左卡尼汀对糖尿病腹膜透析患者外周血T细胞亚群及炎症因子的影响  

Effects of Levocarnitine on Peripheral Blood T Cell Subsets and Inflammatory Factors in Diabetic Patients Underwent Peritoneal Dialysis

作　　者：杨芦蓉[1] 杨林[1] 宋志霞[1] 何川鄂[1] 马岚[2] 

机构地区：[1]三峡大学第一临床医学院/宜昌市中心人民医院肾内科,湖北宜昌443000 [2]三峡大学药学院,湖北宜昌443000

出　　处：《中国药房》2017年第20期2837-2840,共4页China Pharmacy

摘　　要：目的:探讨左卡尼汀对糖尿病腹膜透析患者外周血T细胞及炎症因子的影响。方法:选取2013年9月-2015年10月宜昌市中心人民医院收治的100例糖尿病腹膜透析患者为研究对象,按随机数字表法分为常规治疗组和左卡尼汀组,各50例。常规治疗组患者给予腹膜透析治疗及常规治疗;左卡尼汀组患者在常规治疗组的基础上加用左卡尼汀1.0 g加入0.9%的氯化钠注射液20 m L中,每周3次,静脉注射,连续应用12周。两组患者均于治疗前后检测CD3^+、CD4^+、Th1、Th2及肿瘤坏死因子α(TNF-α)、干扰素γ(INF-γ)、白细胞介素10(IL-10),IL-4含量变化,并比较两组患者T-bet及GATA-3转录因子表达量。结果:治疗后,两组患者CD3^+、CD4^+、Th2细胞、GATA-3表达量及IL-10、IL-4水平均显著升高,Th1细胞、T-bet表达量及TNF-α、INF-γ水平显著降低,且左卡尼汀组显著优于常规治疗组,差异均有统计学意义(P<0.05)。结论:左卡尼汀可通过改善T细胞亚群及Th1/Th2细胞亚群,从而改善患者的炎症状态,促进相关转录因子表达。OBJECTIVE： To investigate the effects of levocarnitine on peripheral blood T cell subsets and inflammatory factors in diabetic patients underwent peritoneal dialysis. METHODS： A total of 100 diabetic patients underwent peritoneal dialysis in selected as research objects were divided into conventional therapy group and levocarnitine group according to random number table, with 50 cases in each group. Conventional therapy group received peritoneal dialysis and conventional therapy. Levocarnitine group was additionally given levocarnitine 1.0 g added into 0.9% Sodium chloride injection 20 mL intravenously, 3 times a week, on the basis of conventional therapy group for 12 weeks. CD3＋, CD4＋, the proportion of Th1 and Th2, the contents of TNF-α, INF-γ, IL-10 and IL-4 in supernatant were all detected before and after treatment. The expression of T-bet and GATA-3 were compared between 2 groups. RESULTS： After treatment, CD3＋, CD4＋, Th2 cells, GATA-3 expression and IL-10, IL-4 levels were significantly increased, the expression of Th1 cells, T-bet content and TNF-α and INF-γ were significantly reduced, and levcarnitine group was significantly better than conrentional therapy group, with statistically significant （P〈0.05）. CONCLUSIONS： Levocarnitine can improve inflammatory reaction and the expression of related transcription factors by promoting T cell subsets and Th1/Th2 cell subsets.

关 键 词：TH1 TH2 T细胞亚群 炎症因子 左卡尼汀 腹膜透析 

分 类 号：R459.5[医药卫生—治疗学]