山豆根药理毒理研究进展  

Pharmacological effect and toxicology of Sophorae Tonkinensis Radix et Rhizoma

作　　者：陈影[1] 陈两绵[1] 仝燕[1] 游云[1,2] 

机构地区：[1]中国中医科学院中药研究所,北京100700 [2]北京中医药大学中医内科学教育部重点实验室,北京100700

出　　处：《中国中药杂志》2017年第13期2439-2442,共4页China Journal of Chinese Materia Medica

基　　金：中医药行业科研专项(201507004-2)

摘　　要：山豆根为临床常用药,具有抗肿瘤、抗病毒、抑菌、镇痛抗炎、抗肝损伤、抗氧化及增强免疫等多种药理作用,但同时也会导致肝、神经、胃肠道及呼吸中枢等毒性反应。山豆根产生的药效及引起的毒性反应与提取工艺、使用剂量、给药时间有关。因此,探索合适的山豆根提取工艺、毒效剂量范围、毒性物质基础可以为山豆根减毒及临床安全用药提供保障。Sophorae Tonkinensis Radix et Rhizoma,which has been commonly used in clinic,shows activities in antitumor,antivirus,antibacteria,analgesia,anti-inflammation,anti-liver injury,anti-oxidation and immune enhancement,but can cause liver toxicity,neurotoxicity,gastrointestinal toxicity and respiratory toxicity. Its pharmacological effect and toxicity are related to extraction process,dosage and administration time. Therefore,exploration of appropriate extraction process,toxicity-effect dosage range,toxic substance basis provides guarantee for attenuation and safe clinical medication.

关 键 词：山豆根 药理作用 毒性 

分 类 号：R285.5[医药卫生—中药学]