基于细胞自噬探讨补肾中药复方防治动脉粥样硬化的研究思路  

Study on prevention and treatment of atherosclerosis by compound chinese medicine for reinforcing kidney based on cell autophagy

作　　者：曹慧[1] 申定珠[1] 陈川[1] 邢三丽[1] 

机构地区：[1]上海中医药大学上海市中医老年医学研究所,上海200031

出　　处：《中国医药导报》2017年第19期77-80,共4页China Medical Herald

基　　金：国家自然科学基金资助项目(81373706);上海市自然科学基金项目(16ZR1433900);上海市卫计委科研项目(201640217)

摘　　要：动脉粥样硬化(AS)是一种随年龄不断增长、以中老年人为主要发病人群的自身免疫性疾病。自噬是由溶酶体介导的降解细胞内受损细胞器或蛋白质的代谢过程。基于免疫介导的细胞自噬在AS形成、发展中的重要作用以及补肾中药复方有效干预治疗AS的前期研究结果,现拟从细胞自噬角度深入探讨补肾中药复方通过细胞自噬途径干预AS的研究策略。Atherosclerosis （AS） is an autoimmune disease that grows with age and is predominantly in the elderly. Autophagy is a lysosomal-mediated process for the degradation of intracellularly damaged organelles or proteins. Based on the important role of immune-mediated autophagy in the AS formation and development and the effect of compound Chinese Medicine for reinforcing kidney on intervention of AS. This paper intends to explore the research strategy of compound Chinese Medicine for reinforcing kidney by interfering with AS by autophagy pathway.

关 键 词：动脉粥样硬化 衰老 免疫 自噬 补肾中药复方 

分 类 号：R285[医药卫生—中药学]