青娥丸加味联合切开复位内固定术治疗不稳定性骨盆骨折的临床疗效  

Clinical Efficacy of Qing'e Pill Combined with Open Reduction and Internal Fixation for Treating of Unstable Pelvic Fracture

作　　者：帅波[1] 郭晓东[2] 沈霖[1] 杨艳萍[1] 马陈[1] 徐晓娟[1] 夏雪[1] 

机构地区：[1]华中科技大学同济医学院附属协和医院中西医结合科,武汉430022 [2]华中科技大学同济医学院附属协和医院骨科,武汉430022

出　　处：《中西医结合研究》2017年第2期57-60,64,共5页Research of Integrated Traditional Chinese and Western Medicine

基　　金：国家自然科学基金项目(No.81403257;81473492;81273907)

摘　　要：目的研究青娥丸加味联合切开复位内固定术治疗不稳定性骨盆骨折的临床疗效。方法选择2014年1月—2016年1月在本院接受切开复位内固定术治疗的78例骨盆骨折患者,随机分为治疗组和对照组,每组39例,治疗组术后除常规治疗外,加用青娥丸加味辅助治疗6个月,对照组术后仅予以常规治疗。术后3个月和6个月时,比较2组患者Majeed骨盆骨折功能评分;术前及术后6个月时,观察2组患者骨转换标志物β-CTX、N-MID和T-PINP水平。结果术后3个月时,Majeed骨盆骨折功能评分,治疗组为优良率为79.49%;对照组优良率为82.05%,治疗组临床疗效与对照组比较,差异无统计学意义(P>0.05)。术后6个月时,Majeed骨盆骨折功能评分,治疗组优良率为94.87%;对照组优良率为84.62%,治疗组临床疗效显著优于对照组(P<0.05)。术前2组患者骨转换标志物β-CTX、N-MID和T-PINP水平比较,差异无统计学意义(P>0.05),术后6个月时,治疗组患者骨转换标志物β-CTX、N-MID和T-PINP水平均明显低于对照组(均P<0.05)。结论切开复位内固定术治疗不稳定性骨盆骨折的临床疗效满意,术后配合中药方青娥丸加味,可有效改善骨转化,进一步改善患者预后。Objective To detect the clinical efficacy of Qing'e pill combined with open reduction and internal fixation in the treatment of unstable pelvic fracture.Methods Seventy-eight cases of pelvic fractures treated with open reduction and internal fixation from January 2014 to January 2016 in our hospital were divided into treatment group and control group randomly,39 cases in each group.The patients in treatment group were given routine treatment combined with Jiawei Qing'e pill orally post-operation,while the patients in control group were given routine treatment only.The Majeed scores of the patients in the two groups were analyzed and compared at 3 and 6 months after operation.The bone turnover markers beta-CTX,N-MID and T-PINP levels in the two groups were compared before and 6 months after the operation.Results Three months after operation,the excellent rate was 79.49% in the treatment group,which was not statistically different from 82.05% in the control group(P>0.05).Six months after operation,the excellent rates were 94.87% in the treatment group and 84.62% in the control group,and there was significant difference between two group(P<0.05).There was no significant difference between two group in bone turnover markers,such as beta-CTX,N-MID and T-PINP levels before operation.But 6 months after operation,the beta-CTX,N-MID and T-PINP levels in the treatment group were significantly lower than those in the control group(all P<0.05).Conclusion Open reduction and internal fixation is effective for treating of unstable pelvic fractures.Traditional Chinese medicine Jiawei Qing'e pill post-operation combined with open reduction and internal fixation,can effectively improve the bone transformation,and further improve the prognosis of patients.

关 键 词：切开复位内固定术 骨盆骨折 青娥丸 骨转换 

分 类 号：R687.3[医药卫生—骨科学]