Acupotomy versus sodium hyaluronate for treatment of knee osteoarthritis in rabbits  

作　　者：Ding Yu Yuan Xueling Wang Yongcheng Wang Aiyuan Shi Xian Wang Lu Daniela Litscher Ingrid Gaischek Irmgard Th.Lippe Gerhard Litscher 

机构地区：[1]Department of Acupuncture&Moxibustion,People's Liberation Army General Hospital,Beijing 100853,China [2]Instituteof Orthopedics,People's Liberation Army General Hospital,Beijing 100853,China [3]Research Unit for Complementary and Integrative Laser Medicine,Research Unit of Biomedical Engineering in Anesthesia and Intensive Care Medicine,and Traditional Chinese Medicine Research Center Graz,Medical University of Graz,8036 Graz,Austria [4]Institute of Experimental and Clinical Pharmacology,Medical University of Graz,8036 Graz,Austria

出　　处：《Journal of Traditional Chinese Medicine》2017年第3期404-411,共8页中医杂志（英文版）

基　　金：Supported by Beijing medicine research Development Fund:A Clinical Study On ltrasound-guided Acupotomy Treatment of Knee Osteoarthritis(No.SF-2009-46)

摘　　要：OBJECTIVE: To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis(KOA).METHODS: Twenty rabbits were divided randomly into four groups(n = 5 in each): a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor(VEGF) expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS: Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group(P < 0.01), and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection(P < 0.01).CONCLUSION: Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF.OBJECTIVE： To investigate the possible advantages of acupotomy over sodium hyaluronate injection for the treatment of knee osteoarthritis（KOA）.METHODS： Twenty rabbits were divided randomly into four groups（n = 5 in each）： a control group,model group, acupotomy group, and sodium hyaluronate injection group. The model, acupotomy,and sodium hyaluronate groups underwent anterior cruciate ligament transection plus partial medial meniscectomy. Sodium hyaluronate injection and acupotomy were administered to the respective groups from weeks 5 to 8, and samples of the tibial plateau and medial condyle of the femur were collected in week 9. Vascular endothelial growth factor（VEGF） expression was assessed in cartilage and subchondral bone by immunohistochemical staining.RESULTS： Articular cartilage degeneration was less pronounced in the acupotomy compared with the model and sodium hyaluronate groups. VEGF expression levels in cartilage and subchondral bone were increased in the model group compared with the control group（P 〈 0.01）, and acupotomy had a more pronounced therapeutic effect than sodium hyaluronate injection（P 〈 0.01）.CONCLUSION： Acupotomy and sodium hyaluronate injection may both reduce degeneration in the cartilage and subchondral bone in KOA based on the results from a rabbit model, but acupotomy improved the histopathology and reduced the VEGF content more effectively than sodium hyaluronate injection, probably by reducing venous stasis and intraosseous pressure. Acupotomy may improve KOA by lowering VEGF.

关 键 词：Osteoarthritis  knee Acupuncture appa-ratus Hyaluronic acid Vascular endothelial growthfactors Venous stasis Cartilage degeneration 

分 类 号：R245[医药卫生—针灸推拿学]