针刺疗法联合塞来昔布对老年类风湿性关节炎患者血清MMP-3,IL-6及自身抗体水平的影响  

Effect of Acupuncture Combined with Celecoxib on the Serum Levels of MMP-3, IL-6 and Autoantibodies of Elderly Patients with Rheumatoid Arthritis

作　　者：陈杰[1] 刘江涛[1] 杨举广 韩兆铭 葛文龙[1] 韩复光 

机构地区：[1]湖北医药学院附属襄阳市第一人民医院骨科,湖北襄阳441000

出　　处：《现代生物医学进展》2017年第18期3513-3516,共4页Progress in Modern Biomedicine

基　　金：湖北省自然科学基金项目(2004ABA193)

摘　　要：目的:研究针刺疗法联合塞来昔布对老年类风湿性关节炎患者的临床疗效及其对患者血清基质金属蛋白酶-3(MMP-3)、白细胞介素-6(IL-6)及自身抗体水平的影响。方法:选取2014年10月至2015年9月本院收治的86例类风湿性关节炎患者,随机分为观察组(43例)和对照组(43例)。对照组使用塞来昔布胶囊治疗,观察组在对照组基础上联合针刺疗法。分析和比较两组患者临床疗效、治疗前后20 m步行时间、晨僵时间、关节压痛数、治疗前后MMP-3、IL-6及自身抗体水平的变化。结果:观察组总有效率显著高于对照组[90.70%(39/43)比65.12%(28/43)](P<0.05)。治疗后,两组患者20m步行时间、晨僵时间、关节压痛数均较治疗前显著降低或缩短,其中观察组明显低于或短于对照组(P<0.05)。治疗后,两组患者血清MMP-3、IL-6水平较治疗前显著降低,其中观察组显著低于对照组(P<0.05)。治疗后,两组患者AFA、抗-CCP抗体、抗Sa抗体、AKA、ANA自身抗体阳性率较治疗前显著降低,其中观察组显著低于对照组(P<0.05)。结论:针刺疗法联合塞来昔布治疗老年类风湿性关节炎的临床疗效良好,能有效降低患者血清MMP-3、IL-6水平及自身抗体阳性率。Objective：To study the effect of acupuncture combined with celecoxib on the elderly patients with rheumatoid arthritis and the serum levels ofmetalloproteinase-3 （MMP-3）,interleukin-6 （IL-6） and autoantibodies.Methods：86 elderly patients with rheumatoid arthritis who were treated in our hospital from October 2014 to September 2015 were selected and randomly divided into the observation group and the control group with 43 cases in each group.The patients in the control group were treated with celecoxib capsules,while the patients in the observation group were treated with acupuncture on the basis of the control group.Then the clinical efficacy,time of 20 m walking and morning stiffness,incidence of joint tenderness,and the levels of MMP-3,IL-6 and autoantibody were observed and compared between the two groups before and after the treatment.Results：After treatment,the total effective rate of the observation group was significantly higher than the control group （P〈0.05）,the time of 20 m walking,morning stiffness and joint tenderness of both groups were significantly lower than those before treatment and the observation group were lower than those of the control group （P〈0.05）,the serum levels of MMP-3 and IL-6 in both groups were significantly lower than before,treatment and the observation group were lower than those of the control group （P〈0.05）,the positive rate ofAFA,anti-CCP,anti-Sa,AKA and ANA in both groups were significantly lower than those before,treatment and the observation group were lower than those of the control group （P〈0.05）.Conclusion：Acupuncture combined with celecoxib could decrease the serum levels of MMP-3 and IL-6 and the positive rate of autoantibody in the elderly patients with rheumatoid arthritis.

关 键 词：针刺疗法 塞来昔布 类风湿性关节炎 基质金属蛋白酶-3 白细胞介素-6 

分 类 号：R593.22[医药卫生—内科学] R245[医药卫生—临床医学]