宫颈上皮内瘤变Ⅲ级术后随诊情况及其临床结局分析  

Analysis of the Clinical Outcome and Follow-up Results of Patients with Cervical Intraepithelial Neoplasia Grade Ⅲ

作　　者：董建新 韩翠娜 王艳 江春花 王怡佳 

机构地区：[1]华北理工大学附属医院妇产科,河北唐山063000 [2]华北理工大学中医学院,河北唐山063009

出　　处：《现代生物医学进展》2017年第19期3715-3718,共4页Progress in Modern Biomedicine

基　　金：河北省卫生厅医学科学研究重点项目(201607260)

摘　　要：目的:探讨宫颈上皮内瘤变Ⅲ级患者宫颈冷刀锥切术后的随访情况,并行TCT及HR-HPV监测对随诊情况进行分析。方法:选择我院2013年6月至2015年6月收治的宫颈冷刀锥切术后诊断为宫颈高级别上皮内瘤变(CINIII,HR-HPV阳性)的患者共计150例,分别于锥切术后3、6、12个月进行HR-HPV检测、宫颈液基细胞学(TCT)检查,并分析其随访情况。结果:不同年龄段患者正规随访比例分别为73.91%、78.05%、68.09%、75%,差异无统计学意义(P>0.05)。正规随访患者术后3、6、12个月,HR-HPV的转阴率分别为57.27%、77.27%、89.09%,不同年龄段HR-HPV的转阴率分别为94.12%、93.75%、87.5%、66.67%,随着年龄的增长HR-HPV转阴率逐渐下降,而大于56岁的患者HR-HPV转阴率最低,与其他各年龄段比较,差异具有统计学意义(P<0.05),各组正规随访患者TCT检查在随访期间均为阴性。结论:宫颈锥切术能够切除宫颈病变组织,但不能完全清除HR-HPV病毒,术后对各年龄段人群均需严密随诊。Objective：To explore the clinical outcome and follow-up results of patients with cervical intraepithelial neoplasia grade Ⅲ.Methods：150 patients with cervical intraepithelial neoplasia grade Ⅲ who were admitted for the first time in our hospital from June 2013 to June 2015 were followed up.Results：The rates of regular follow-up were 73.91%,78.05%,68.09%,75% in different age groups.There was no statistical difference between different age groups （P〉O.05）.The negative rate was 57.27% after three months,77.27% after six months,89.09% after twelve months in regular follow up patients.The negative rates of HR-HPV were 94.12%,93.75%,87.5%,66.67% in different age groups.And the HR-HPV negative rate of more than 56-year-old patients was the lowest,compared with other age groups（P〈0.05）.TCT was negative in different age groups.Conclusions：Cervical conization could remove diseased tissues,but couldn＇t clear the HPV virus.We should pay attention to follow the patients.

关 键 词：宫颈上皮内瘤变Ⅲ级 术后随诊 HR-HPV 宫颈液基细胞学检查 

分 类 号：R711.74[医药卫生—妇产科学] R737.33[医药卫生—临床医学]