左旋肉碱凝胶剂的制备及体外透皮特性研究  

Preparation of L-carnitine gel and study on its in vitro transdermal permeability

作　　者：王晓阁 陈莉[2] 李京洋[2] 张永红[3] 郭文健[3] 闫帅[3] 熊金玲[4] 向江滔 张岭[2] 

机构地区：[1]天津军事物流基地中心仓库第二分库,天津300182 [2]武警后勤学院生药学与药剂学教研室,天津300309 [3]武警后勤学院学员二旅一营,天津300309 [4]武警后勤学院学员二旅六营,天津300309 [5]武警后勤学院学员二旅七营,天津300309

出　　处：《武警后勤学院学报（医学版）》2017年第4期318-320,共3页Journal of Logistics University of PAP（Medical Sciences）

基　　金：武警后勤学院基础研究项目(WHJ2014010)

摘　　要：【目的】研究不同凝胶基质对凝胶剂中左旋肉碱体外经皮渗透的影响,并评价凝胶剂作为左旋肉碱透皮给药载体的可行性。【方法】制备不同基质的左旋肉碱凝胶,采用改良的Franz扩散池,用离体大鼠皮肤进行体外经皮渗透实验,以HPLC法检测接受液中左旋肉碱含量并计算累积渗透量及稳态透皮速率。【结果】以2%羧甲基纤维素钠为基质的左旋肉碱累积透过量最大(7.635 mg/cm^2),透皮速率常数(J)为0.2308 mg·(cm^2·h)^(-1),均优于甲基纤维素和卡波姆。【结论】选用2%羧甲基纤维素钠作为左旋肉碱凝胶剂的基质较好。【Objective】To study the effects of different gel matrices on the in vitro transdermal permeability of L-carnitine, and evaluate the feasibility of transdermal delivery carriers containing L-carnitine.【Methods】The different gels containing L-carnitine were formulated. The transdermal permeation test was carried out by using improved Franz diffusion cell through in vitro rat skin. The concentration of L-carnitine in receptor medium was measured by HPLC. Then the cumulative penetration amount and steady transdermal penetration rate were calculated.【Results】The cumulative penetration amount of the gel was the most（7.635 mg/cm^2）when the matrix was 2% carboxy methyl cellulose sodium（CMC-Na）. The penetration rate constant（J） was 0.2308 mg·（cm^2·h）^-1. The indexes of CMC-Na were better than those of methyl cellulose（MC） and carbomer.【Conclusion】The optimum matrix for L-carnitine transdermal system is 2% CMC-Na.

关 键 词：左旋肉碱 凝胶 经皮渗透 

分 类 号：R943[医药卫生—药剂学]