妥洛特罗贴剂联合孟鲁司特治疗毛细支气管炎疗效观察  

Clinical Observation of Tulobuterol Patch Combined with Montelukast in Treatment of Bronchiolitis

作　　者：孙萌[1] 郭爱丽[2] 毕玫荣[2] 李峰[2] 窦冬冬[2] 朱薇薇[2] 

机构地区：[1]潍坊医学院儿科学教研室,山东潍坊261053 [2]山东大学附属济南市中心医院儿科

出　　处：《潍坊医学院学报》2017年第4期285-287,共3页Acta Academiae Medicinae Weifang

摘　　要：目的探讨妥洛特罗贴剂联合孟鲁司特治疗婴幼儿毛细支气管炎的临床疗效。方法将96例毛细支气管炎患儿按照随机双盲的方法分为对照组和治疗组,各48例。两组患儿均给予氧疗、抗病毒、平喘、祛痰等常规治疗,治疗组在此基础上给予妥洛特罗贴剂外用联合孟鲁司特口服,连用7d。观察两组患儿在主要症状及体征方面缓解(或消失)的时间。结果对照组与治疗组总有效率分别为72.92%,95.83%,治疗组总有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗组患儿咳嗽、喘憋及肺部哮鸣音消失时间均短于对照组,两组比较具有统计学意义(P<0.05)。结论妥洛特罗贴剂联合孟鲁司特治疗毛细支气管炎可明显改善主要临床症状及体征,总有效率高,依从性好,且未见明显不良反应,值得临床推广。Objective To explore the therapeutic efficacy of tulobuterol patch combined with montelukast therapy of bronchiolitis in children. Methods Ninety-six infants with bronchiolitis were randomly assigned to either a control group（ n = 48） or a treatment group（ n = 48） by double-blind method. Both groups of children were given oxygen therapy,anti-virus,anti-asthma,expectorant and other regular treatment. On the basis of this,the treatment group was treated with external tulobuterol patch and oral montelukast with seven days. The times of main symptoms,signs relief or disappearance were observed between the two groups. Results The total effective rate in the treatment group（ 95. 83%）was very higher than that in the control group（ 72. 92%）,and the difference was statistically significant（ P〈0. 05）. The disappearance time of cough,dyspnea and lung wheezing in the control group were shorter than those in the trial group,there was a remarkable difference（ P〈0. 05）. Conclusions Tulobuterol patch combined with montelukast can obviously improve the major clinical symptoms and signs in treatment capillarity bronchitis,with higher efficiency,better compliance,less adverse reactions,which is deserved to be popularized clinically.

关 键 词：妥洛特罗 孟鲁司特 毛细支气管炎 

分 类 号：R725.6[医药卫生—儿科]