心房颤动患者血清网膜素-1与心房纤维化血清生化标记物的相关性研究  

Correlations between serum omentin-1 and biochemical markers of atrial fibrosis in atrial fibrillation patients

作　　者：王冰[1] 黄陵生[1] 李良海[1] 李梦秋[1] 金平[1] 

机构地区：[1]荆州市中心医院,荆州434020

出　　处：《内科急危重症杂志》2017年第3期224-225,246,共3页Journal of Critical Care In Internal Medicine

摘　　要：目的:探讨心房颤动患者血清网膜素-1与心房纤维化血清生化标记物之间的相关性。方法:采用酶联免疫吸附法检测阵发性、持续性房颤患者及健康对照组血清网膜素-1、Ⅰ型胶原羧基端前肽(PⅠCP)、Ⅲ型胶原前多肽(PⅢNP)、基质金属蛋白酶-1(MMP-1)、组织型基质金属蛋白酶抑制因子-1(TIMP-1)、透明质酸(HA)和层黏连蛋白(LN)的水平,线性相关分析网膜素-1与以上血清标记物的相关性。结果:持续性房颤患者血清网膜素-1的水平为(46.4±5.7)μg/L,显著低于阵发性房颤患者(64.1±5.3)μg/L和对照组患者(87.9±4.4)μg/L(均P<0.05);持续性房颤患者血清PⅠCP(173.4±7.5)μg/L、PⅢNP(7.0±0.5)μg/L、MMP-1(17.1±0.7)μg/L、TIMP-1(151.5±6.3)μg/L、HA(139.8±5.8)μg/L和LN(145.1±8.3)μg/L的水平均显著高于阵发性房颤组和对照组(均P<0.05);此外,血清网膜素-1与以上心房纤维化血清生化标记物呈显著负相关。结论:持续性房颤患者血清网膜素-1的水平显著降低,且与心房纤维化血清生化标记物呈显著负相关,提示血清网膜素-1与房颤患者心房纤维化密切相关。Objective： To discuss the correlation between serum omentin-1 and atrial fibrosis biochemical markers in patients with atrial fibrillation（ AF）. Methods： Enzyme-linked immunosorbent assay was used to detect the levels of serum omentin-1,C-terminal propeptide of procollagen type Ⅰ（ PⅠCP）,N-terminal type Ⅲ collagen peptide（ PⅢNP）,matrix metalloproteinase-1（ MMP-1）,tissue matrix metalloproteinases inhibitory factor-1（ TIMP-1）,hyaluronic acid（ HA） and layer adhesion proteins（ LN） of paroxysmal AF patients,persistent AF patients and healthy control group. The linear correlation analysis was applied to determine the correlations of omentin-1 and the above serum biomarkers. Results： Level of serum omentin-1 in persistent AF patients was（ 46. 4 ± 5. 7） μg/L,significantly lower than that of patients with paroxysmal AF [（ 64. 1 ±5. 3） μg/L] and that of healthy control group [（ 87. 9 ± 4. 4） μg/L]（ all P 〈 0. 05）. And levels of PⅠCP [（ 173. 4 ± 7. 5）μg/L],PⅢNP [（ 7. 0 ± 0. 5） μg/L],MMP-1 [（ 17. 1 ± 0. 7） μg/L],TIMP-1 [（ 151. 5 ± 6. 3） μg/L],HA [（ 139. 8 ± 5. 8）μg/L]and LN [（ 145. 1 ± 8. 3） μg/L]in persistent AF group were significantly higher than those of paroxysmal AF group and healthy control group（ all P 〈 0. 05）. Additionally,it was shown that serum omentin-1 was negatively correlated with the above biochemical markers of atrial fibrosis. Conclusion： Serum omentin-1 level in patients with persistent AF was significantly low and negatively correlated with biochemical markers of atrial fibrosis,which indicated that serum omentin-1 level might be closely related to atrial fibrosis in AF patients.

关 键 词：网膜素-1 心房颤动 纤维化 

分 类 号：R541.75[医药卫生—心血管疾病]