中西医结合治疗对慢性阻塞性肺疾病急性加重期患者炎症因子及免疫功能的影响  

Effect of Integrated Chinese and Western Medicine Therapy on Inflammatory Factor and Immune Function of Patients with AECOPD

作　　者：洪世海 夏清华 黄光辉 程继荣 何慧嫦 

机构地区：[1]清远市中医院,广东清远511500

出　　处：《新中医》2017年第7期40-43,共4页New Chinese Medicine

基　　金：清远市科技计划项目(2014B065)

摘　　要：目的:观察中西医结合治疗慢性阻塞性肺疾病急性加重期(AECOPD)患者的临床效果以及对炎症因子、免疫功能的影响。方法:将60例AECOPD患者按随机数字表法分为治疗组和对照组各30例。2组均予现代医学综合性常规治疗,治疗组则加服补肾益肺健脾膏方,并配合离子导入活血祛痰中药。2组疗程均为6周。比较2组治疗前后血清前降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、Ig A、Ig G、Ig M、CD3^+、CD4^+、CD4^+/CD8^+比值及自然杀伤(NK)细胞活性。结果:治疗后,2组血清PCT、hs-CRP、TNF-α、IL-6含量均较治疗前降低,IL-10含量均较治疗前增加,差异均有统计学意义(P<0.05)。2组各指标比较,差异均无统计学意义(P>0.05)。治疗组血清Ig A、Ig G、Ig M、CD3^+、CD4^+、CD4^+/CD8^+比值及NK细胞活性均较治疗前增加,差异均有统计学意义(P<0.05);对照组以上7项指标值与治疗前比较虽有升高趋势,但差异均无统计学意义(P>0.05);2组以上7项指标比较,差异均有统计学意义(P<0.05)。结论:在现代医学规范化治疗的基础上加用补肾益肺健脾膏方内服联合离子导入活血祛痰中药治疗AECOPD,能够有效抑制炎症反应,增强机体免疫功能。Objective： To observe the clinical effect of integrated Chinese and western medicine therapy for acute exacerbation of chronic obstructive pulmonary disease（AECOPD）,and its effect on inflammatory factor and immune function.Methods：Selected 60 patients with AECOPD and divided them into the treatment group and the control group being 30 cases in each,according to the random table method. The two groups were both given standardized treatment of modern medicine,while the treatment group was given Bushen Yifei Jianpi cream formula combined with iontophoresis of Chinese medicine for promoting blood circulation to remove blood stasis additionally. Treatment of the two groups both lasted for six weeks.Compared serum procalcitonin（PCT）, high sensitive C-reactive protein（hs-CRP）, tumor necrosis factor-α（TNF-α）,interleukin-6（IL-6）, interleukin-10（IL-10）, immune genetic algorithm（IGA）, immunoglobulin G（IgG）, immunoglobulin M（IgM）,CD3^＋,CD4^＋,CD4^＋/CD8^＋ and natural killer（NK） cell activity of the two groups before and after treatment. Results：After treatment, content of serum PCT, hs-CRP,TNF-α and IL-6 of the two groups was all lower than those before treatment, IL-10 content of two groups was both increased（P〈0.05）. Compared every index of the two groups, the difference was not significant（P〈0.05）. Comparing with those before treatment, serum IgA, IgG, IgM, CD3^＋, CD4^＋,CD4^＋/CD8^＋ and NK cell activity of both grous were increased,while the difference in the treatment group before and after treatment being significant（P〈0.05）, the difference in the control group being not significant（P〉0.05）. The difference between the two groups of above seven indexes was significant（P〈0.05）. Conclusion：Based on the standardized treatment of modern medicine, Bushen Yifei Jianpi cream formula combined with iontophoresis of Chinese medicine for promotingblood circulation to remove blood stasis in treating AECOPD can inhibit inflammatory reaction

关 键 词：慢性阻塞性肺疾病(COPD) 肺肾两虚证 痰瘀互结证 中西医结合疗法 补肾益肺健脾膏方 中药离子导入 炎症因子 免疫功能 

分 类 号：R563[医药卫生—呼吸系统]